Guillain-Barre Syndrome

Question 1

Recall the symptoms of Guillain-Barre syndrome

Answer 1

Ascending symmetrical numbness and tingling in limbs (upper/lower/both) accompanied by ascending weakness and arreflexia

Question 2

Recall the pathophysiology of Guillain-Barre

Answer 2

Autoimmune destruction of myelin sheath

Commonly follows campylobacter pylori infection

Question 3

Describe the eventual progression of GBS

Answer 3

Progresses to autonomic dysfunction (may become incompetent) and eventually respiratory depression due to effect on diaphragm

Question 4

What is the antibody present in GBS?

Answer 4

Anti-GM1

Question 5

Describe the CSF composition in GBS

Answer 5

High protein

Low WCC

Question 6

Recall the symptoms of Miller Fisher syndrome

Answer 6

Descending weakness/numbness

TRIAD of ophthalmaplegia, ataxia and areflexia

Question 7

Where does Miller-Fisher syndrome usually first show symptoms?

Answer 7

Eyes

Question 8

Which antibody is present in Miller-Fisher syndrome?

Answer 8

Anti-GQ1b