Guided Notes Flashcards
What is Acute Kidney Injury (AKI)?
The term used to encompass the entire scope of the syndrome, ranging from a slight deterioration in kidney function to a severe impairment.
What is Acute tubular necrosis (ATN)?
The most common intra-renal cause of AKI in hospitalized patients.
Primarily result of ischemia, nephrotoxins, or sepsis.
What is Acute tubular necrosis (ATN)?
The most common intra-renal cause of AKI in hospitalized patients.
Primarily result of ischemia, nephrotoxins, or sepsis.
What is Anuria?
No urine output, often seen with urinary tract obstructions.
What is Azotemia?
An accumulation of nitrogenous waste products (urea nitrogen, creatinine) in the blood.
What is Azotemia?
An accumulation of nitrogenous waste products (urea nitrogen, creatinine) in the blood.
What is Chronic Kidney Disease (CKD)?
This involves progressive, irreversible loss of kidney function.
What is diuresis?
Increased or excessive production of urine.
What is Extracellular fluid (ECF)?
Fluid found outside of the cell.
What is Glomerular filtration rate (GFR)?
The amount of blood filtered each minute by the glomeruli.
Normal is about 125mL/min
What does hypertonic mean?
Higher osmolality than blood.
What IV fluids are hypertonic?
D5NS
D51/2NS
D10W
3%NaCl
What are hypertonic fluids used for?
To move fluid from cells and interstitial spaces to the vascular space (blood stream).
What does hypotonic mean?
Lower osmolality than blood.
What type of IV fluids are Hypotonic?
0.45% NS
What are Hypotonic fluids used for?
“Blows up cells”
Used to treat cellular dehydration (DKA)
What does isotonic mean?
Same osmolality as blood
What type of fluids are isotonic?
0.9% NS
Lactated Ringers
What are isotonic fluids used for?
Used to expand vascular space.
Used for dehydration, hypovolemia, shock.
What is hypovolemia?
Loss of body fluids, inadequate fluid intake, or plasma to interstitial fluid shift
- Dehydration - Loss of water without loss of sodium.
How do we treat hypovolemia?
Correct the underlying cause and replace water and electrolytes with oral fluids, blood products, or proper IV solutions.
What is hypervolemia?
Excess intake of fluids, abnormal retention of fluids, or interstitial to plasma fluid shift.
What is a symptom of hypervolemia?
Weight gain is most common.
How do we treat hypervolemia?
Remove fluid without changing electrolyte composition or osmolality of ECF.
Diuretics, Fluid restrictions, Sodium restriction, Removal of fluid to treat ascites or pleural effusion.
What is Oliguria?
A reduction in urine output of less than 400mL/day
Is the most common initial manifestation of AKI.
What is Paresthesia?
Tickling or pins and needles caused by pressure on or damage to peripheral nerves.
What is tonicity?
The capability of a solution to modify the volume of cells by altering their water content.
What is Uremia?
A condition involving high levels of waste product in the blood. Likely occurs in final stage of CKD.
What is Diffusion?
Movement of molecules through a semipermeable membrane from a higher concentration area to a lower concentration.
What is Active Transport?
The process in which molecules move against the concentration gradient. External energy is needed for this process.
What is Omosis?
The movement of water down a concentration gradient from a region of low solute to one of high solute.