GU/Renal

Question 1

Paramesonephric Ducts makes up what part of the vagina?

Answer 1

1/3 of the upper vagina

Question 2

Urogenital sinus makes up what part of the vagina?

Answer 2

Lower 1/3 of vagina

Question 3

SRY gene
- Where is it located?
- Purpose?

Answer 3

SRY located on the Y Chromosome
- Helps male gonads secrete testosterone from leydig cells & Mullerian inhibitory factor from Sertoli Cells

Question 4

Genital Tubercle gives rise to?

Answer 4

Glans Penis (Male)
Glans clitoris (Female)

Question 5

Urogenital Folds gives rise to?

Answer 5

Ventral Aspect of Penis (Males)
Labia Minora (Females)

Question 6

Labioscrotal swellings

Answer 6

Scrotum (Males)
Labia Majora (Females)

Question 7

In Males the urogenital sinus gives rise to:

Answer 7

Bladder, urethra, prostate and bulbourethral glands

Question 8

Females urogenital sinus gives rise to

Answer 8

Bladder, urethra, lower 2/3 of vagina and bartholion glands

Question 9

What do these males structures relate to in female structures?:

Male:
1. Glans Penis
2. Foreskin
3. Penile Shaft
4. Scrotum
5. Testes
6. Prostate Gland
7. Cowper’s Glands

Answer 9

Female:
1. Glans clitoris
2. Clitoral Hood
3. Labia Minora
4. Labia Majora
5. Ovaries
6. Skerie’s Ducts
7. Bartholin Glands

Question 10

Wilm’s Tumor
*What?
*What syndrome is it associated with?
*What is the underlying problem?
*Genetics
*Presents with?
*What type of capsule is the tumor surrounded by?
*Histology

Answer 10

*What?: Most common renal malignancy in children

*Associated w/: WAGR syndrome
- W: Wilm’s Tumor
- A: Aniridia (absence of iris)
- G: GU Anomalies
- R: Retardation (intellecutal diasbility)

*Underlying problem: abnormal renal development which leads to the proliferation of the metanephric blastema without normal tubular and glomerular differentiation

*Genetics: WT1 gene, p53 gene, FWT1 & FWT2 gene

*Presents with: cysts, hemorrhage, and necrosis, abdominal mass, abdominal pain, fever & hematuria, hypertension

*Tumor is surrounded by: pseudocapsule

*Histology: triphasic pattern, consists of tubules, solid sheet of small round cells, and stroma

Question 11

During renal development, what produces a structure that then signals the original structures further development?

Answer 11

The metanephros forms around 5th week of gestation and forms the metanephrogenic mesoderm and ureteric bud. The ureteric bud beings to develop & signals the metanephros to begin renal tubule development