GU Male MDT Flashcards
Hematuria visible to the naked eye
Gross Hematuria
Hematuria only detectible by examination of the urine sediment by microscopy, or urinalysis
Microscopic
Both gross and microscopic hematuria require:
Evaluation
An upper urinary tract source (kidneys and ureters) can be identified in __% of patients with gross or microscopic hematuria
10%
Hematuria
Stone disease accounts for __%
40%
Hematuria
__% caused by kidney disease
20%
Hematuria
__% from renal cell carcinoma
10%
Hematuria
__% caused by urothelial cell carcinoma of the ureter or renal pelvis
5%
The lower tract source of gross hematuria is most commonly from:
Urothelial carcinoma of the bladder
Microscopic hematuria in the male is most commonly from:
Benign prostatic hyperplasia
Gross hematuria
What may help localize the disease?
Description of timing
The presence of blood at the beginning of the urinary stream that clears during the stream, implies an anterior penile urethral source
Initial hematuria
The presence of the blood at the end of the urinary stream, implies a bladder neck or prostatic urethral source
Terminal hematuria
The presence of blood through the urinary stream, implies a bladder or upper tract source
Total hematuria
Hematuria associated with renal colic suggests:
Ureteral stone
Irritative voiding symptoms in a young woman may suggest:
Acute bacterial infection and associated cystitis
In the absence of other symptoms, gross hematuria may be more indicated of:
Tumor
Labs:
Hematuria
UA
Urine Culture
BUN and Creatinine
Imaging:
Hematuria
CT scan of the upper tract w/o contrast
Cystoscopy
Indicated in patients with gross hematuria or those over 35 years with asymptomatic hematuria
Cystoscopy
Treatment for hematuria
Depends on the underlying disease process
Hematuria UA
Proteinuria and casts suggest:
Renal Origin
What kind of bacteria are responsible for most of the UTIs?
Coliform bacteria (E. Coli)
Most common route for UTI
Ascending infection from the urethra
Infection of the bladder
Cystitis
Cystitis is most commonly caused by:
Coliform bacteria
-E. Coli
Gram-positive bacteria
-Enterococci
Uncomplicated cystitis in men is rare and suggests:
Infection from stones
Prostatitis
Chronic urinary retention
Signs and symptoms:
- Irritative voiding symptoms
- Suprapubic discomfort
- Women have hematuria after sex
- Usually afebrile
- Exam may elicit suprapubic tenderness with palpation
Cystitis
Noninfectious cystitis can be caused by:
Pelvic irradiation
Chemotherapy
Bladder carcinoma
Interstitial cystitis
Voiding dysfunction disorders
Psychosomatic disorders
Cystitis UA may reveal
Pyuria
Bacteriuria
Various degrees of hematuria
Treatment for cystitis
Antimicrobial therapy
- Ciprofloxacin
- Nitrofurantoin
- Trimethoprim/sulfamethoxazole (Bactrim)
Urinary analgesics
-Phenazopyridine
Women who have more than __ episodes of cystitis per year are considered candidates for prophylactic antibiotic therapy
3
The three most commonly used oral agents for Cystitis prophylaxis
Trimethoprim-sulfamethoxazole (40/200mg) daily
Nitrofurantoin (100mg) daily
Cephalexin (250mg) daily
Infectious inflammatory disease involving the kidney parenchyma and renal pelvis
Pyelonephritis
Most common causative agents that cause pyelonephritis
Gram-negative bacteria:
- Klebsiella
- Proteus
- E Coli
- Enterobacter
- Pseudomonas
Bacteria commonly seen in pyelonephritis
Gram-positive
- Enterococcus faecalis
- Staphylococcus
What bacteria causes Pyelonephritis from a hematogenous route?
Staph Aureus
Signs and symptoms
- Fever
- Flank pain
- Irritative voiding symptoms (urgency, frequency, dysuria)
- Shaking chills
- Associated nausea & vomiting
- Diarrhea
- Tachycardia
- Costovertebral angle tenderness is usually pronounced
Pyelonephritis
Pyelonephritis lab findings
CBC: Leukocytosis & Left Shift
UA: Pyuria, bacteriuria, hematuria, white cell casts
Urine Culture: Heavy growth of offending organism
Blood culture may be positive
Imaging for pyelonephritis
Renal Ultrasound
-May show hydronephrosis (stone/obstruction)
Treatment for pyelonephritis
Antibiotic therapy (2-week therapy)
- Ampicillin & Gentamicin IV
- Ciprofloxacin PO
- Levofloxacin PO
- Trimethoprim-sulfamethoxazole PO
Urinary Analgesics
-Phenazopyridine
Pyelonephritis
IV antibiotics are continued for __ hours after the fever resolves and oral antibiotics are then given to complete the 14 day course of therapy
24 hours
Pyelonephritis
Fevers may persist for up to __ hours even with appropriate antibiotics
72
Inflammation and infection of the prostate gland
Acute Prostatitis
Prostatitis is usually caused by:
Gram negative
- E Coli
- Pseudomonas Species
Prostatitis is less commonly caused by:
Gram-positive
-Enterococci
Most likely routes for infection of prostatitis
Ascent up the urethra
Reflux of infected urine into the prostatic ducts
(Lymphatic and hematogenous routes are rare)
Signs and symptoms
- Perineal, sacral, or suprapubic pain
- High fever
- Irritative voiding symptoms
- Obstructive symptoms, urinary retention
- Warm and often exquisitely tender prostate (gentle exam)
Prostatitis
Laboratory findings in prostatitis
CBC: Leukocytosis and left shift
UA: Pyuria, bacteriuria, hematuria
Treatment for prostatitis
Antibiotics (4-6 weeks)
- Ampicillin & Gentamicin IV
- Ciprofloxacin PO
- Levofloxacin PO
- Trimethoprim-sulfamethoxazole PO
Tylenol
NSAIDs
Stool softeners
Prostatitis
IV Antibiotics are continued for ___ hours after the fever resolves and oral antibiotics are given to complete the ___ week course therapy
24-48 hours
4-6 weeks
May evolve from acute bacterial prostatitis
Many men have no history of acute infection
Chronic bacterial prostatitis
What organism is associated with chronic bacterial prostatitis infection?
Gram Neg Rods (MOST COMMON)
Enterococcus (Gram Positive)
Prostate may be:
Normal
Boggy
Indurate
Chronic bacterial prostatitis
Pelvic radiographs or transrectal U/S may show:
Prostatitis calculi
Treatment for Chronic bacterial prostatitis
Antimicrobials (6-12 weeks Therapy)
- Trimethoprim-sulfamethoxazole PO
- Ciprofloxacin PO
- Levofloxacin PO
NSAIDs
Sitz Baths
Chronic bacterial prostatitis optimal duration of antibiotic therapy length
6-12 weeks
Inflammation and/or infection of the epididymis
Epididymitis
Sexually transmitted forms of epididymitis usually occur in men under:
40
Sexually transmitted epididymitis is caused by:
Chlamydia trachomatis
Neisseria gonorrhoeae
Non-sexually transmitted forms of epididymitis occur in:
Older men
Associated with UTI and Prostatitis
Non-sexually transmitted epididymitis is typically caused by:
Gram-negative rods
- E coli
- Klebsiella
Signs and symptoms
- May follow acute physical strain, trauma, or sex
- Associated Sx: Urethritis, Cystitis
- Pain in the scrotum, may radiate to flank
- Fever
- Scrotal swelling
Epididymitis
Physical findings
Early course of epididymitis:
The epididymis may be distinguishable from the testes
Later course of epididymitis
The teste and epididymis appear as one enlarged tender mass
Elevation of the scrotum above the pubic symphysis improves pain from epididymitis
Prehn sign
Epididymitis
Testing for suspected chlamydia and gonorrhoeae
NAAT (Nucleic acid amplification testing)
Imaging for epididymitis
Ultrasound
Treatment for sexually transmitted epididymitis
Ceftriaxone IM & Doxycycline PO
Treatment for non-sexually transmitted epididymitis
Trimethoprim/sulfamethoxazole
Ciprofloxacin
Levofloxacin
Complications of epididymitis that is delayed or inadequate treatment may result in:
Epididymo-orchitis (Testicle Inflammation)
Decreased fertility
Abscess formation
Epididymitis
Refer to urology when:
Persistent symptoms and infection despite antibiotic therapy
Signs of sepsis or abscess formation
Renal calculi is also known as:
Urolithiasis
Men are more effected by urolithiasis than women by:
2.5:1
How many major types of urinary stones are there?
5
Most common type of urinary stone
Calcium (85%)
Weather
Contributing factors of renal calculi
High humidity & elevated temperatures
Higher incidence rates of renal calculi are associated with what disease processes?
Sedentary lifestyle
Hypertension
Carotid calcification
Cardiovascular disease
Diet that is associated with renal calculi
High protein and salt intake
Inadequate hydration
Signs and symptoms:
- Pain often occurs suddenly in the flank
- Nausea and vomiting
- Constantly moving to find a comfortable position
- May be episodic
Renal calculi
Urinalysis findings in renal calculi
Hematuria (90%)
Urinary pH
Imaging for Renal Calculi
Plain abdominal radiograph (Kidney, Ureter and Bladder)
Renal U/S
Spiral CT in prone position
Renal calculi
KUB with renal U/S can diagnose up to __% of stones
80%
Renal calculi
What has increased sensitivity and specificity over other tests?
Spiral CT
Stones smaller than ____mm in diameter on a plain abdominal radiograph usually pass spontaneously
5-6 mm
Renal Calculi
Medications that can increase the rate on spontaneous stone passage
Alpha-blockers (Tamsulosin)
NSAIDs
-With or without a low dose oral corticosteroid
Stones that require surgical removal include those that are showing signs of:
Obstruction or infection
Procedures for stone removal include:
Ureteroscopy stone extraction
Extracorporeal shock wave lithotripsy
The greatest importance in reducing stone recurrence
Increased fluid intake
Renal calculi
Increasing fluid intake to ensure a voided volume of:
2.5 L/day
Stones
Patients are encouraged to ingest fluids during meals, __ hours after each meals, and prior to sleep
2 hours
Renal calculi
Sodium intake should be restricted to:
150 mEq/day
Renal calculi
Protein intake should be:
Spread out through the day
Limited to 1g/kg/day
Disposition
Obstructing stone with associated infection is a:
MEDEVAC
Renal calculi
Signs/symptoms of infection:
Fever
Tachycardia
Elevated WBC
Referral to urology is warranted if the stone fails to pass within:
4 weeks
Two types of erectile tissue
Corpus cavernosa
Corpus spongiosum
Normal male erection is a neurovascular event relying on:
Intact autonomic and somatic nerve supply
Arterial blood flow
Smooth and striated musculature of the corpora cavernosa and pelvic floor
Erection is caused and maintained by:
Increase in arterial flow
Relaxation of the smooth muscle
Increase in venous resistance
The key transmitter that initiates and sustains erections
Nitric oxide
The consistent inability to attain or maintain a sufficiently rigid penile erection for sexual performance
Erectile dysfunction (ED)
ED has what kind of etiologies?
Organic and psychogenic
Organic erectile dysfunction may be an early sign of:
Cardiovascular disease
Loss of libido may indicate:
Androgen deficiency
Loss of erections may result from:
Arterial
Venous
Neurogenic
Hormonal
Psychogenic
The most common cause of erectile dysfunction is:
Decrease in arterial flow resultant from progressive vascular disease
The ability to attain but not maintain an erection may be the first sign of:
Endothelial dysfunction and further Cardiovascular risk
What medications are associated with erectile dysfunction?
Antihypertensive
Antidepressant
Opioids
Fibrotic disorder of the tunica albuginea of the penis resulting in varying degrees of penile pain, curvature, or deformity
Peyronie disease
The loss of seminal emission
Anejaculation
Anejaculation may result from
Androgen deficiency
Sympathetic denervation as a result of spinal cord injury
Labs for erectile dysfunction:
Lipid profile (dyslipidemia)
Glucose (diabetes)
Testosterone
Free testosterone must be drawn at what hours?
8-10 am
Treatment for ED:
Lifestyle modification (smoking, alcohol, diet, exercise)
Hormonal replacement
Oral agents (phosophodiesterase-5 inhibitors)
ED
Men with psychogenic component benefit from:
Sexual health therapy or counseling
Occurrence of penile erection lasting longer than 4 hours
Priapism
Ischemic injury of the corpora cavernosa from venous congestion and cessation of arterial inflow
Priapism
Initial treatment for priapism
Aspiration of blood from the penis and injection of sympathomimetic drugs (epinephrine/phenylephrine)