GSSE pharmacology

Question 1

what bacteria are you specificaly trying to carget by synergestic administration of betalactam adn gentamycin?

Answer 1

enterococcus, because it is resistant to both individually but not together.
The beta-lactams break the bacterial cell wall and allow gentamicin to enter the bacterial cytoplasm where it can access the ribosomal target, explaining why this combination can be useful against gram-positive bacterial infection.

Question 2

what type of bacteria is gentamycin most appropriately targeting?

Answer 2

Enterobacteriaceae family (e.g., Escherichia coli, Klebsiella pneumoniae, Serratia spp., and Enterobacter spp.), Pseudomonas aeruginosa, and some strains of Neisseria, Moraxella, and Haemophilus genera.

Question 3

you should avoid the concomitant administration of gentamicin with ____?

Answer 3

potent diuretics (i.e., ethacrynic acid, furosemide, etc.) as diuretics may cause ototoxicity. Additionally, when diuretics are administered intravenously, it enhances gentamicin toxicity by increasing the drug concentration in serum and tissue.