Growth Factors involved in Regeneration and Repair Flashcards
Epidermal growth factor (EGF) source
Activated Macrophages
Salivary glands
Keratinocytes
Epidermal growth factor (EGF) function
Mitogenic for keratinocytes and fibroblasts
Stimulates keratinocyte migration
Stimulates formation of granulation tissue
Transforming growth factor α (TGF-α) source
Activated macrophages
Keratinocytes
Other cell types
Transforming growth factor α (TGF-α) function
Stimulates proliferation of hepatocytes and many other epithelial cells
Hepatocyte growth fact (HGF) source
“Scatter factor”
Fibroblasts
Stromal cells of the liver
Endothelial cells
Hepatocyte growth factor (HGF) function
Enhances proliferation of hepatocytes and other epithelial cells
Increases cell motility
Vascular endothelial growth factor (VEGF) source
Mesenchymal cells
Vascular endothelial growth factor (VEGF) function
Stimulates proliferation of endothelial cells
Increases vascular permeability
Platelet-dervied growth factor (PDGF) source
Platelets
Macrophages
Endothelial cells
Smooth M. cells
Keratinocytes
Platelet-dervied growth factor (PDGF) function
Chemotactic for neutrophils, macrophages, fibroblasts and smooth M cells
Activates and stimulates proligeration of fibroblasts, endothelial and other cells
Stimulates ECM protein synthesis
Fibroblast Growth Factors (FGFs) source
Macrophages
Mast cells
Endothelial cells
Other cell types
Fibroblast Growth Factors (FGFs) function
Chemotactic and mitogenic for fibroblasts
Stimulates angiogenesis and ECM protein synthesis
Transforming Growth factor-β (TGF-β) source
Platelets
T-lymphocytes
Macrophages
Endothelial cells
Keratinocytes
Smooth M cells
Fibroblasts
Transforming Growth factor-β (TGF-β) function
Chemotactic for leukocytes and fibroblasts
Stimulates ECM protein synthesis
Suppresses acute inflammation
Keratinocyte growth factor (KGF) source
Fibroblasts
