Growth Adaptations, Cell Injury/death Flashcards
Increase in Cell size
hypertrophy
Increase in cell #
hyperplasia
Hypertrophy requires
gene activation
protein synth
organelle production
Tissues that can only undergo hypertrophy–permanent tissues
Cardiac
sk. mm
Nerves
Hyperplasia that does not progress to dysplasia
BPH
Decrease in stress –> decrease in organ size
atrophy
Ubiquitin proteosome degradation
cytoskeleton marked with ubiquitin and destroyed
cell decreases in size –> atrophy
Atrophy mechanism that decreases cell #
apoptosis
Change in cell type
Metaplasia
Mechanism of Metaplasia
reprogramming of stem cells
reversible
Metaplasia with no risk of progression to CA
apocrine metoplasia of the breast
Vitamin necessary for differentiation of surface epithelium
Vitamin A
Disordered Cellular Growth
Dysplasia
reversible
irreversible progression of dysplasia
Carcinoma
Failure of cell to be produced during embryogenesis
aplasia