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Group review Flashcards

1
Q

cytokine storm cytokines

A

IL6
TNFa
IL10

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2
Q

staph aureus superantigens/toxins

A

SEB
SEC2
TSST

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3
Q

strep pyogenes superantigen/toxin

A

SPE-C

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4
Q

which portal of entry favors stimulations of immune response?

A

subQ
intradermal

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5
Q

on what chromosome is:
- beta2
- MHC molecules

A

beta2 - chromo 15
MHC molecules - chromo 6

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6
Q

B cell receptor editing order of chain rearrangement

A

kappa light chain tried first, then lambda light chain if needed

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7
Q

what do treg express and what do they need to survive?

A

CD4, CD25, FoxP3
need IL2 and TGFbeta

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8
Q

target of xolair

A

IgE C epsilon 3

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9
Q

stem cell factor aka _

A

kit ligand

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10
Q

which marker is used to determine basophil activation?

A

CD63, CD203c

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11
Q

Eosinophil production and lineage differentiation is dependent on which transcription factor?

A

GATA-1

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12
Q

Which eosinophil chemo-attractants is most commonly implicated in the pathogenesis of eosinophilic esophagitis?

A

eotaxin-1

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13
Q

What is the other name for CCL11?

A

eotaxin

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14
Q

which chemokine receptor is important for B cells to migrate into the white pulp of the spleen?

A

CXCR5 (Bad B cells pay $5 to get into white pulp/KKK)

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15
Q

Which chemokine receptor plays a critical role in dendritic cell migration into the lymph nodes and is expressed at high levels on naïve T-cells to promote their interaction?

A

CCR7

Nemo is a naive 7yo T cell who goes along (migrates) with Dory the dendritic cell (has dendritic appendages)

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16
Q

Which Toll Like Receptors (TLRs) is located in the cytosol?

A

3,7,8,9

17
Q

direct precursor of a myeloid dendritic cell?

A

monocyte

18
Q

what is efferocytosis?

A

macrophages clear up apoptotic cells after infection /injury

19
Q

What cytokines promote maturation of eos?

A

GM-CSF, IL-3, IL-5

20
Q

Which dendritic cell produces type 1 interferon in response to viruses?

A

Plasmacytoid dendritic cells

21
Q

What cytokine targets immature lymphoid progenitors to induce T lymphocytes?

A

IL-7

22
Q

What chemokine receptor do activated DCs express?

A

CCR7

23
Q

Which cytokine uniquely promotes airway mastocytosis and mast cell progenitor development andlocalization to the airway?

A

IL-9

24
Q

TRPA1 receptor

A

activated by Carbon dioxide, cold, mechanical stimulation, and strong odors leading to rhinitis symptoms due to non-antigenic irritants.

25
Q

what exposure causes contact Derm to chromium?

A

wet cement, or leather tanned with salts containing chromate

26
Q

What is CR1/CD35?

A

erythrocyte bound C3b receptor
highly efficient in clearing immune complexes via the reticuloendothelial system

27
Q

Which most potent anaphylatoxin contributes to major inflammatory response in large part due to the early recruitment of neutrophils?

A

C5a

28
Q

What type of receptor is the glucocorticoid receptor?

A

nuclear receptor

29
Q

What drug causes a potentially fatal hypersensitivity reaction in HLA B5701-positive individuals?

A

Abacavir

30
Q

Type IVa reactions involve the secretion of large amounts of which cytokine?

A

IFN-gamma

AI boards (3 decks)

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