Group review

Question 1

cytokine storm cytokines

Answer 1

IL6
TNFa
IL10

Question 2

staph aureus superantigens/toxins

Answer 2

SEB
SEC2
TSST

Question 3

strep pyogenes superantigen/toxin

Answer 3

SPE-C

Question 4

which portal of entry favors stimulations of immune response?

Answer 4

subQ
intradermal

Question 5

on what chromosome is:
- beta2
- MHC molecules

Answer 5

beta2 - chromo 15
MHC molecules - chromo 6

Question 6

B cell receptor editing order of chain rearrangement

Answer 6

kappa light chain tried first, then lambda light chain if needed

Question 7

what do treg express and what do they need to survive?

Answer 7

CD4, CD25, FoxP3
need IL2 and TGFbeta

Question 8

target of xolair

Answer 8

IgE C epsilon 3

Question 9

stem cell factor aka _

Answer 9

kit ligand

Question 10

which marker is used to determine basophil activation?

Answer 10

CD63, CD203c

Question 11

Eosinophil production and lineage differentiation is dependent on which transcription factor?

Answer 11

GATA-1

Question 12

Which eosinophil chemo-attractants is most commonly implicated in the pathogenesis of eosinophilic esophagitis?

Answer 12

eotaxin-1

Question 13

What is the other name for CCL11?

Answer 13

eotaxin

Question 14

which chemokine receptor is important for B cells to migrate into the white pulp of the spleen?

Answer 14

CXCR5 (Bad B cells pay $5 to get into white pulp/KKK)

Question 15

Which chemokine receptor plays a critical role in dendritic cell migration into the lymph nodes and is expressed at high levels on naïve T-cells to promote their interaction?

Answer 15

CCR7

Nemo is a naive 7yo T cell who goes along (migrates) with Dory the dendritic cell (has dendritic appendages)

Question 16

Which Toll Like Receptors (TLRs) is located in the cytosol?

Answer 16

3,7,8,9

Question 17

direct precursor of a myeloid dendritic cell?

Answer 17

monocyte

Question 18

what is efferocytosis?

Answer 18

macrophages clear up apoptotic cells after infection /injury

Question 19

What cytokines promote maturation of eos?

Answer 19

GM-CSF, IL-3, IL-5

Question 20

Which dendritic cell produces type 1 interferon in response to viruses?

Answer 20

Plasmacytoid dendritic cells

Question 21

What cytokine targets immature lymphoid progenitors to induce T lymphocytes?

Answer 21

IL-7

Question 22

What chemokine receptor do activated DCs express?

Answer 22

CCR7

Question 23

Which cytokine uniquely promotes airway mastocytosis and mast cell progenitor development andlocalization to the airway?

Answer 23

IL-9

Question 24

TRPA1 receptor

Answer 24

activated by Carbon dioxide, cold, mechanical stimulation, and strong odors leading to rhinitis symptoms due to non-antigenic irritants.

Question 25

what exposure causes contact Derm to chromium?

Answer 25

wet cement, or leather tanned with salts containing chromate

Question 26

What is CR1/CD35?

Answer 26

erythrocyte bound C3b receptor highly efficient in clearing immune complexes via the reticuloendothelial system

Question 27

Which most potent anaphylatoxin contributes to major inflammatory response in large part due to the early recruitment of neutrophils?

Answer 27

C5a

Question 28

What type of receptor is the glucocorticoid receptor?

Answer 28

nuclear receptor

Question 29

What drug causes a potentially fatal hypersensitivity reaction in HLA B5701-positive individuals?

Answer 29

Abacavir

Question 30

Type IVa reactions involve the secretion of large amounts of which cytokine?

Answer 30

IFN-gamma