Group review Flashcards
cytokine storm cytokines
IL6
TNFa
IL10
staph aureus superantigens/toxins
SEB
SEC2
TSST
strep pyogenes superantigen/toxin
SPE-C
which portal of entry favors stimulations of immune response?
subQ
intradermal
on what chromosome is:
- beta2
- MHC molecules
beta2 - chromo 15
MHC molecules - chromo 6
B cell receptor editing order of chain rearrangement
kappa light chain tried first, then lambda light chain if needed
what do treg express and what do they need to survive?
CD4, CD25, FoxP3
need IL2 and TGFbeta
target of xolair
IgE C epsilon 3
stem cell factor aka _
kit ligand
which marker is used to determine basophil activation?
CD63, CD203c
Eosinophil production and lineage differentiation is dependent on which transcription factor?
GATA-1
Which eosinophil chemo-attractants is most commonly implicated in the pathogenesis of eosinophilic esophagitis?
eotaxin-1
What is the other name for CCL11?
eotaxin
which chemokine receptor is important for B cells to migrate into the white pulp of the spleen?
CXCR5 (Bad B cells pay $5 to get into white pulp/KKK)
Which chemokine receptor plays a critical role in dendritic cell migration into the lymph nodes and is expressed at high levels on naïve T-cells to promote their interaction?
CCR7
Nemo is a naive 7yo T cell who goes along (migrates) with Dory the dendritic cell (has dendritic appendages)
Which Toll Like Receptors (TLRs) is located in the cytosol?
3,7,8,9
direct precursor of a myeloid dendritic cell?
monocyte
what is efferocytosis?
macrophages clear up apoptotic cells after infection /injury
What cytokines promote maturation of eos?
GM-CSF, IL-3, IL-5
Which dendritic cell produces type 1 interferon in response to viruses?
Plasmacytoid dendritic cells
What cytokine targets immature lymphoid progenitors to induce T lymphocytes?
IL-7
What chemokine receptor do activated DCs express?
CCR7
Which cytokine uniquely promotes airway mastocytosis and mast cell progenitor development andlocalization to the airway?
IL-9
TRPA1 receptor
activated by Carbon dioxide, cold, mechanical stimulation, and strong odors leading to rhinitis symptoms due to non-antigenic irritants.
what exposure causes contact Derm to chromium?
wet cement, or leather tanned with salts containing chromate
What is CR1/CD35?
erythrocyte bound C3b receptor
highly efficient in clearing immune complexes via the reticuloendothelial system
Which most potent anaphylatoxin contributes to major inflammatory response in large part due to the early recruitment of neutrophils?
C5a
What type of receptor is the glucocorticoid receptor?
nuclear receptor
What drug causes a potentially fatal hypersensitivity reaction in HLA B5701-positive individuals?
Abacavir
Type IVa reactions involve the secretion of large amounts of which cytokine?
IFN-gamma
