Gremlin: Drug Delivery and Dosage Forms Flashcards
Approximately ____ of children aged 6-11 years old described the inability to swallow a tablet
56%
capsule considerations
must determine formulation of capsule and contents
challenges with liquid dosage forms
not all meds are commercially available as liquid, and if they are, may have many concentrations -> risk for med errors
Use smallest volume possible
what is the primary source of non-compliance in children
palatability
tube admin considerations
- what is the site of absorption
- can the med contact plastic
- will the med clog the tube
IM and SQ admin considerations
- can only admin a limited volume (common challenge specific to peds)
- muscle and fat mass limit utility
- can be used for emergency or single med admin such as vaccines
1.
powder paper
the use of crushed tablets combined with filler to create “measurable” quantity for smallest dosage needs
USP <795>
for extemporaneous preparations that do not have available, published literature related to stability
tablet formulation consdieration
can it be split or crushed
chew tab formulation cosniderations
child needs to be able to chew
mini tab formualtion consideration
max mg/tab -> may need to give several tabs to reach desired dose
ODT formulation considerations
usually can’t split (expection zofran)
ODF (film) formulation consideration
can cut for a more tailored dose, but is expensive
powder packet fomrulation consideration
hard to titrarte, powder may need to be mixed with a large volume of liquid
sprinkle formulation consideration
limited dose flexibility
why do we avoid benzoyl alcohol in peds
neurotox and metabolic acidosis, esp in neonates
why do we avoid ethanol in peds
neurotox
why do we avoid polysorbates in peds
- liver and kidney failure
- ascities
- thrombocytopenia
- pulmonary deterioration
why do we avoid propylene glycol in peds
- seizures
- neurotox
- hyperosmalarity
- metabolic acidosis
why do we avoid sorbitol in peds
osmotic diarrhea
inhalation drug device consideration in peds
devices made for adults -> default for peds is nebulizer (but there’s education required for parents and the machien is bulky)
nasal drug device consideration for peds
made for adults and hard to admin for certain ages
rectal formulation considerations
make poo,will expel drug, bad for absorption
topical medication considerations for peds
BSA:med, cocnerns for systemic absoroption
