Gray's - Head & Neck - Jen Flashcards
A 2-month-old male infant had a small pit at the
anterior border of the sternocleidomastoid muscle, with mucus dripping intermittently from the opening. The pit extended to the tonsillar fossa as a branchial fistula. Which of the following embryologic structure(s) is (are) involved in this anomaly?
A. Second pharyngeal arch
B. Second pharyngeal pouch and groove
C. Third pharyngeal pouch
D. Thyroglossal duct
E. Second pharyngeal pouch and cervical sinus
E. The child in this problem suffers from a fistula that indicates an open malformation.
This implies that the defect must be due to failure of closure for both an internal and an external structure. A branchial fistula results from failure of closure of both the second pharyngeal pouch and the cervical sinus, the cervical sinus being the consolidation of the second through fourth pharyngeal clefts, external structures. The second pharyngeal groove merges with the third and fourth pharyngeal grooves to form the cervical sinus.
A 2-day old infant was born with a cleft palate. The major portion of the palate develops from which of the following embryonic structures? A. Lateral palatine process B. Median palatine process C. Intermaxillary segment D. Median nasal prominences E. Frontonasal eminence
A. Lateral palatine process
The largest part of the palate is formed by the
secondary palate, which is embryologically derived
from the lateral palatine processes.
A 3-day-old infant has a small area of the right iris missing, and a diagnosis of coloboma of the iris is made. Which of the following is the most likely embryologic cause of the coloboma?
A. Failure of the retinal/choroid fissure to close
B. Abnormal neural crest formation
C. Abnormal interactions between the optic vesicle
and ectoderm
D. Posterior chamber cavitation
E. Weak adhesion between the inner and outer
layers of the optic vesicle
A. Failure of the retinal/choroid fissure to close
A coloboma of the iris is caused by failure of the retinal fissure to close during the sixth week.
Early closure of the fontanelles of the infant skull can result in compression of the brain, restricting brain growth. Which of the following fontanelles is located at the junction of sagittal and coronal sutures and at what age does this fontanelle typically close?
A. Posterior fontanelle, which closes at about 2 years
B. Mastoid fontanelle, which closes at about 16 months
C. Lambdoid fontanelle, which closes at 8 months to 1 year
D. Sphenoidal fontanelle, which closes at 3 years
E. Anterior fontanelle, which closes at 18 months
E. Anterior fontanelle, which closes at 18 months
The anterior fontanelle is located at the junction
of the sagittal and coronal sutures and closes at
around 18 months of age.
A 3-year-old boy is admitted to the hospital because of a soft, anterior, midline cervical mass. When the patient is asked to protrude his tongue, the mass in the neck is observed to move upward. Which of the following is the most likely diagnosis?
A. A thyroglossal duct cyst
B. Defect in sixth pharyngeal arch
C. A branchial cyst
D. Cystic fistula of the third pharyngeal arch
E. Defect in first pharyngeal arch
A. A Thyroglossal duct cyst
Thyroglossal duct cysts occur due to retention
of a remnant of the thyroglossal duct along the path followed by the descending thyroid gland during development. The path begins from the foramen cecum of the tongue and descends in the midline to the final position of the thyroid.
A 2-day-old infant male has a noticeable gap in his upper lip. The diagnosis is a cleft lip. Failure of fusion of which of the following structures is the most likely cause of this anomaly?
A. Lateral nasal and maxillary prominences/ processes
B. Medial nasal prominences/processes
C. Lateral nasal and medial nasal prominences/ processes
D. Lateral prominences/processes
E. Maxillary prominences/processes and the inter maxillary segment
E. Maxillary prominences/processes and the intermaxillary segment
The most common cause of cleft lip is failure of fusion of the maxillary process and the inter maxillary segment.
A 3-day-old male has a noticeably small mandible. A CT scan and physical examinations reveal hypoplasia of the mandible, cleft palate, and defects of the eye and ear. Abnormal development of which of the following pharyngeal arches will most likely produce such symptoms? A. First arch B. Second arch C. Third arch D. Fourth arch E. Sixth arch
A. First arch
The listed symptoms are typical of first arch syndrome because the first arch normally gives rise to muscles of mastication, mylohyoid, anterior belly of the digastric, tensor tympani, tensor veli palatini, malleus, and incus.
A 5-day-old infant male has an abnormally large head. A CT scan examination reveals enlarged lateral and third ventricles but a normal-size fourth ventricle. Stenosis of the cerebral aqueduct (of Sylvius) is suspected. Which of the following conditions will be characteristic of these symptoms? A. Nonobstructive hydrocephalus B. Anencephaly C. Obstructive hydrocephalus D. Meroanencephaly E. Holoprosencephaly
C. Obstructive hydrocephalus
Obstructive hydrocephalus, in this case resulting from obstruction of the cerebral aqueduct, refers to a condition in which flow of cerebrospinal fluid (CSF) is obstructed within the ventricular system. This leads to pressure increasing in the CSF above the obstruction, explaining the enlarged lateral and third ventricles.
A 3-month-old male infant has a lump in his neck. A biopsy of the lump shows it to be thymic tissue. Based on embryonic origin, which of the following additional structures is most likely to have an ectopic location? A. Jugulodigastric lymph node B. Lingual tonsil C. Parathyroid gland D. Submandibular gland E. Thyroid gland
C. Parathyroid gland
Both the inferior parathyroid glands and the thymus are derived from the third pharyngeal pouch. Therefore, an ectopic thymus is likely to be associated with ectopic parathyroid tissue, indicating abnormal development of the third pharyngeal pouch.
A 3-month-old male is under observation in the pediatric clinic. The patient has no thymus, congenital parathyroidism, and thyroid hypoplasia. Abnormal development of which of the following pharyngeal pouches or arches will most likely produce these defects? A. First and second B. Second and third C. Third and fourth D. Fourth E. Fourth and sixth
C. Third and fourth
The defect is likely in the development of third and fourth pharyngeal pouches because the superior parathyroid glands are derived from the fourth pouch, whereas the inferior parathyroid glands are derived from the third pouch In addition, the third pouch gives rise to the thymus, and the parafollicular cells of the thyroid gland are derived from the fourth pharyngeal pouch.
Cleft lip, with or without cleft palate occurs about once in 1000 births. Which of the following is considered to be the most important causative factor in the production of this anomaly?
A. Riboflavin deficiency
B. Infectious disease
C. Mutant genes
D. Cortisone administration during pregnancy
E. Irradiation
C. Mutant genes
Whereas all forms of clefts are considered to have a multifactorial etiology, cleft lip in particular seems to have a strong genetic factor. This has been determined using studies of twins. The other listed factors may or may not play a role in the development of a cleft lip, but genetics remains the most important causative factor.
A 5-week-old male infant is born without a thymus or inferior parathyroid glands. Which of the following pharyngeal arches is most likely involved? A. First B. Second C. Third D. Fourth E. Fifth
C. Third
Absence of the thymus and inferior parathyroid glands would be due to defective development of the third pharyngeal pouch, their normal site of origin.
A 5-day-old infant was born with a laryngeal defect. The greater cornu and the inferior part of the hyoid bone were absent at birth. Failure of development of which of the following embryonic structures most likely led to these defects? A. Maxillary prominence B. Mandibular prominence C. Second pharyngeal arch D. Third pharyngeal arch E. Fourth pharyngeal arch
D. Third pharyngeal arch
The third pharyngeal arch gives rise to the greater cornu and lower part of the hyoid bone in addition to the stylopharyngeus muscle.
A 22-year-old woman visits the outpatient clinic with a painless swelling on the right side of her neck. A CT scan examination reveals a well-defined cystic mass at the angle of the mandible, just anterior to the sternocleidomastoid muscle. What is the most likely diagnosis? A. Dermoid cyst B. Inflamed lymph node C. Accessory thyroid tissue D. Thyroglossal duct cyst E. Lateral cervical cyst
E. Lateral cervical cyst
A lateral cervical cyst is caused by remnants of the cervical sinus and would present anterior to the sternocleidomastoid.
A 5-day-old infant is diagnosed with a noncommunicating hydrocephalus. Which of the following is most likely to lead to such a condition?
A. Obstruction in the circulation of the cerebrospinal fluid
B. Excess production of cerebrospinal fluid
C. Increased size of the head
D. Disturbances in the resorption of cerebrospinal fluid
E. Failure of the neural tube to close
A. Obstruction in the circulation of the cerebrospinal fluid
Noncommunicating hydrocephalus, also known as obstructive hydrocephalus, is due to an obstruction to flow of CSF within the ventricular system.
A 5-day-old infant was born with a normal Apgar score. One month later the external acoustic meatus was atretic Which of the following conditions was the most likely cause of this defect?
A. Otic pit did not form.
B. Development of the first pharyngeal pouch
was affected.
C. Meat 1 plug did not canalize.
D. Auricular hillocks did not develop.
E. The tubotympanic recess degenerated.
C. Meat 1 plug did not canalize.
A normal Apgar score indicates that the child appeared normal and healthy at birth, based on skin color, heart rate, reflexes, muscle tone, and breathing. An atretic external acoustic canal occurs due to failure of the meatal plug to canalize, an event that normallyoccurs in late fetal life.
A 50-year-old woman complained of pain over her chin and lower lip. A few days later small vesicles appeared over the same area and soon began erupting. She was diagnosed with a dermatomal herpes zosterinflammation (shingles). Which of the following nerves was most likely responsible for the transmission of the virus in this case? A. Auriculotemporal B. Buccal C. Lesser petrosal D. Mental E. Infraorbital
D. Mental
The chin and lower lip area are supplied by the mental nerve, a branch of the inferior alveolar nerve, which in turn is a branch of the mandibular division of the trigeminal nerve.
A 68-year-old woman is suffering from excruciating, sudden bouts of pain over the area of her mid face. Laboratory studies indicate that she has tic douloureux (trigeminal neuralgia). Which ganglion is the location of the neural cell bodies of the nerve mediating the pain? A. Geniculate B. Trigeminal (semilunar or Gasserian) C. Inferior glossopharyngeal D. Otic E. Pterygopalatine
B. Trigeminal (semilunar or Gasserian)
The semilunar ganglion, also known as the trigeminal or Gasserian ganglion, is the location of the sensory neuron cell bodies of the trigeminal nerve. Tic douloureux is a condition in which pain occurs over the area of distribution of trigeminal nerve branches.
A 17-year-old woman is admitted to the hospital with signs of cavernous sinus thrombosis, as revealed by radiographic and physical examinations. Thrombophlebitis in the “danger area” of the face can spread to the cavernous sinus and involve the ophthalmic branch of the trigeminal nerve. Which of the following symptoms will most likely be present during physical examination?
A. Pain in the hard palate
B. Anesthesia of the upper lip
C. Pain from the eyeball
D. Pain over the lower eyelid
E. Tingling sensation over the buccal region of
the face
C. Pain from the eyeball
The ophthalmic branch of the trigeminal nerve supplies sensory innervation to the eyeball, leading to p in upon damage.
A 34-year-old man is admitted to the hospital with severe headaches, dizziness, and vomiting. Imaging studies reveal a tumor at the hypoglossal canal. Which of the following muscles will most likely be affected? A. Geniohyoid B. Mylohyoid C. Palatoglossus D. Genioglossus E. Thyrohyoid
D. Genioglossus
A tumor at the hypoglossal canal would compress the hypoglossal nerve and affect the genioglossus, a muscle it supplies.
A 45-year-old female is admitted to the hospital with severe headaches, dizziness, and vomiting. Radiographic examination reveals an intracranial tumor. Upon physical examination the patient has dryness of the nasal and paranasal sinuses, loss of lacrimation,and loss of taste from the anterior two thirds of the tongue. Which of the following structures is most likely involved with the tumor? A. Auriculotemporal nerve B. Lesser petrosal nerve C. Facial nerve D. Inferior salivatory nucleus E. Pterygopalatine ganglion
C. Facial nerve
The superior salivatory nucleus is the autonomic nucleus for the facial nerve Parasympathetic fibers carried by the greater petrosal branch of the facial nerve are responsible for supply of the lacrimal gland and sinuses, via the pterygopalatine ganglion. The geniculate ganglion contains the cell bodies for taste from the anterior two thirds of the tongue carried by the chorda tympani branch of the facial nerve. This branch also carries the parasympathetic supply for the submandibular and sublingual salivary glands.
A 17-year-old female was admitted to the hospital with a high fever. Following intravenous administration of antibiotics, a routine CT scan revealed a “thoracic outlet” syndrome. Which symptom would most likely result from this syndrome?
A. Problems with respiration because of pressure
on the phrenic nerve
B. Reduced blood flow to the thoracic wall
C. Reduced venous return from the head and neck
D. Numbness in the upper limb
E. Distention of the internal jugular vein
D. Numbness in the upper limb
Thoracic outlet syndrome is characterized by the presence of a cervical rib, accessory muscles, or connective tissue bands that constrict the limited dimensions of the thoracic outlet. The cervical rib is usually located on the C7 vertebra and can impinge on the brachial plexus, resulting in loss of some feeling to the upper limb.
A 31-year-old female is admitted to the hospital after an automobile collision. A CT scan examination reveals a large hematoma inferior to the right jugular foramen. Physical examination reveals right pupillary constriction (miosis) and anhydrosis (loss of sweating) of the face. Which of the following ganglia is most likely affected by the hematoma? A. Submandibular B. Trigeminal (semilunar or Gasserian) C. Superior cervical D. Geniculate E. Ciliary
C. Superior cervical
The superior cervical ganglion (SCG), which is the uppermost part of the sympathetic chain, supplies sympathetic innervation to the head and neck. The usual symptoms for SCG injury are mitosis and anhydrosis in the head and neck region.
A 35-year old male patient is admitted to the hospital with severe headaches. A CT scan evaluation reveals a tumor in the infra temporal fossa. Physical examination reveals loss of general sensation from the anterior two thirds of his tongue, but taste and salivation are intact. Wh ch of the following nerves is most likely affected by the tumor?
A. Lingual proximal to its junction with the
chorda tympani
B Chorda tympani
C. Inferior alveolar
D. Lesser petrosal
E. Glossopharyngeal
A. Lingual proximal to its junction with the
chorda tympani
The lingual nerve joins the chorda tympani in the infratemporal fossa, and a lesion to the lingual nerve before it joins the chorda tympani would account for the loss of general sensation, with no loss to the special sense of taste and saliva production
A 70-year-old man is admitted to the hospital with chronic headache and enlarged lymph nodes. A CT scanshows a tumor at the jugular foramen. Which of the following would be the most likely neurologic deficit?
A. Loss of tongue movements
B. Loss of facial expression
C. Loss of sensation from the face and the scalp
D. Loss of hearing
E. Loss of gag reflex
E. Loss of gag reflex
The jugular foramen is the route of exit for three nerves (glossopharyngeal, vagus, and accessory nerves) and one vein (internal jugular) from the cranial cavity. The glossopharyngeal nerve provides the sensory input for the gag reflex, whereas the vagus nerve provides the motor output. Nerve compression within this foramen would lead to a loss of both systems and thus no gag reflex.
A 40-year-old unconscious man is admitted to the emergency department after being hit in the head with a baseball. A CT scan examination reveals a fractured pterion and an epidural hematoma. Branches of which of the following arteries re most likely to be injured? A. External carotid B. Superficial temporal C. Maxillary D. Deep temporal E. Middle meningeal
E. Middle meningeal
The middle meningeal artery is a branch of the maxillary artery and courses between the dura mater and skull close to the area of the pterion. Any fracture or impact trauma to this location typically results in a laceration of the middle meningeal artery resulting in an epidural hematoma