Granulopiosis Flashcards
Human stem cell
Morphological unrecognizable
Small percentage
Self renew
Multipotent
Progenitor stem cell
Morphological unrecognizable
Small percentage
Irreversible lineage commitment
Blast cell
The 1st recognizable cell in lineage but still u can tell lymphoyed or myloid
Mitoyicakku active
Mature cell
Majority of cells
Deformable
Loss adherence receptor
What are the different hematopitic stages with dates ?
Which bones ?
In fetal life :
In yolk sac until 12th week
Liver and spleen until 20 week
Bone marrow from 20 the week to adulthood
Axial bones Cranial Vertebral Sternum Ribs Long bones Pelvis
How is granulopiosis under normal physiological status ?
How is granulopisis under pathological status ?
In normal status
Granuopiosis occur in the intramedullary hematopoisis ( bone marrow )
Under pathological status :
Yellow marrow converted to red ( hypercelluraity)
Liver spleen can also be resumed ( regression)
And the production will be multiplied six times
A hierachy of cells
Multipotent hematopoitic stem cells HSC
Then the lineage commitment progenitor cells
Maturing and more granulocytes
What are the key points of granulopoiesis ?
Highly regulated complex system of cell production
Involves proliferation and differentiation
Involves close interaction of bone marrow microenviromental elements ( stem cell niche ( with precursor cells
Cell maturation is a physiological continuum from
stem cells to cells of specific lineage granulocytes
Also i want to add this point that after cell mature stem cell nieche regulate their function as well
What are the three components that granulopoisis depend on ?
1 . Microenviroment or bone marrow stroma ( local control )
- Stem and progenitor cells
- Growth factors ( humoral control )
Granulopiosis lineage ?
HSC human stem cell Progenitor myloid Myloidblast Promyloidcyte Myloid cyte Metamyloid cyte Neutrophil
What is the bone marrow structure ?
The bone marrow is encased by ?
Cortical bone
Transverse bone
Consists of highly organized meshwork of thin walled cappillary venous sinusis with surrounding extracellular cappillary venous sinuses with surrounding extracelluar matrx that fills the space betweeb the bony trabecule
What is the basic structural unit of the bone marrow ?
Capillary venous sinus
From where we take bone marrow sample and what do we take exactly ?
From the posterior superior iliac bone
We take
Bone aspirate which is like blood from red marrow
And bone marrow biopsy
Why we need capillary venous sinus ?
We need it for the mature cells to migrate to the blood stream
What is homing ?
Is the process by which stem cells disseminated in blood go to the bone or to the environment it want to live in by attachment to receptors ( local regulation )