Granulation Flashcards
What is Granulation
Granulation is the process of collecting particles together by creating bonds between them . Bonds are formed by
1) Sludging ( Dry Granulation)
2) using a binding agent ( Wet Granulation)
What are the need of granules
To enhance Flow of powders
To produce uniform mixture
To avoid poor content uniformity
To improve compactation
To avoid powder segregation
Types of granulation
1) Wet granulation
2) Dry Granulation
3) Direct compression
What is wet granulation
It is the most widely used method, it involves addition of liquid solution to powder to form wet mass. It is used for products not degraded by moisture and heat
What are the steps of wet granulation
1) Weighing
2) Seiving
3) Pre mixing
4) addition of binder
5) Seiving of wet mass
6) Drying of wet mass
7) Seiving of dried mass
8) Final mixing
What is step 1 Weighing in wet granulation
Accurately weigh all the excepients and api
What is step 2 Seiving in in wet granulation
Seiving reduces particles size and ensure uniform mixing due to similar particle size
It increases surface area, enhance rate of dissolution
What is step 3 Pre mixing in wet granulation
To achieve optimum mixing of different ingredients for wetting
Depends upon formulation
API+ Diluents or API+Diluents+Disintegrators
Step 4 Addition of binder of wet granulation
Binder may be in form of solution, suspension, paste , solvent used should be volatile, non toxic
It converts powder into wet mass
Step5 Seiving of wet mass in wet granulation
Wet mass produced is not of uniform size
Wet mass is seived to obtain uniform size
To increase surface area of wet grains
Increased surface area results in decreased time
Step 6 Drying of wet mass
Seived wet mass is dried either in FBD or Tray dryers
Hot air evaporates solvent leaving behind dried grains , wet mass is dried untill residual moisture content 2-3%
Step 7 Seiving of dried mass in wet granulation
Dried mass is seived to obtain uniform sized grains, Dried mass is passed through a specified seive
Final mixing
Last step of wet granulation
