Gram negative - Treatment

Question 1

Antibiotics used for Gram negative bacteria - 7

Answer 1

Penicillins (Not effective), Penicillins+beta lactamase, Cephalosporin (1+2 Gen. Not effective), Cephalosporin (3+4 Gen.), Carbapnems, Aminoglycosides (Mainly UTI), Flouroquinolones.

Question 2

Cephalosporin - Any good?

Answer 2

3rd and 4th generation are great for Gram negative

Question 3

Penicillins - Any good?

Answer 3

isn’t very good – better when beta lactamase inhibitors are added – prevent the bac from breaking it down

Question 4

Carbapenems - Any good?

Answer 4

Are great ! yay!

Question 5

Aminoglicosides - Any good?

Answer 5

concentrate well in urine – used mostly for UTIs but nephrotoxic (and slightly ototoxic)

Question 6

Fluoroquinolones - Any good?

Answer 6

very good for Gram negative, advantage: abs well via pills can be given PO

Question 7

Gram negative Tx.

Answer 7

for a simple bac give simple antibiotic (ex. No Carbopenems since we don’t want more bacs to be resistant to them, our backup)

Question 8

Pseudomonas Tx. - 3

Answer 8

the only Penicillin that works on it is Pipercillin (given as Pipercillin tazobactam, with inhibitor)

• Cephalosporins don’t work on it, only Ceftazidime
• Carbopenems, only Meropenem and Imipenem