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Gram Negative Flashcards

1
Q

9 -be bacteria

A

Campylobacter jejuni, escherichia coli, haemophilus influenzae, neisseria meningitidis, salmonella, shigella, yersinia enterocolitica, helicobacter pylori, pseudomonas aeruginosa

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2
Q

Campylobacter jejuni shape/ID

A

Helical

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3
Q

escherichia coli shape/ID

A

Bacillus

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4
Q

haemophilus influenzae shape/ID

A

Coccobacillus

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5
Q

neisseria meningitidis shape/ID

A

Diplococcus (intracellular in neutrophils and macrophages)

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6
Q

salmonella shape/ID

A

Bacillus (intracellular)

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7
Q

shigella shape/ID

A

Bacillus

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8
Q

yersinia enterocolitica shape/ID

A

Bacillus

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9
Q

helicobacter pylori shape/ID

A

Helical

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10
Q

pseudomonas aeruginosa shape/ID

A

Bacillus

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11
Q

Bacillus

A

Pseudomonas aeruginosa,helicobacter pylori, yersinia enterocolitica, shigella, salmonella (intracellular), escherichia coli

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12
Q

Pseudomonas aeruginosa,helicobacter pylori, yersinia enterocolitica, shigella, salmonella (intracellular), escherichia coli

A

Bacillus

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13
Q

Helical

A

Helicobacter pylori, campylobacter jejuni

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14
Q

Helicobacter pylori, campylobacter jejuni

A

Helical

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15
Q

Campylobacter Baxter virulence factors

A

Cytothelial distending toxin, S layer (prevents binding of complement)

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16
Q

Campylobacter Baxter condition

A

Diarrhoea + severe abdo pain (IBS and reactive arthritis can follow. Rare: antibody cross reacting to cause guillain-barre)

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17
Q

Campylobacter Baxter treatment

A

Don’t treat, norfloxacin if severe (fluoroquinolone)

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18
Q

Escherichia coli virulence factors

A

variable virulence. Expression of toxin, adhesins and invasin factors, biofilm, flagella.
EPEC - (enteropathic) has short adhesins and shortens villi.
STEC - shiga toxin binds to GB3 halting protein synthesis and causing apoptosis (CNS, kidney effects)

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19
Q

Escherichia coli commensal

20
Q

Escherichia coli condition

A

Neonate meningitis. Urinary tract infections. Diarrhoea/colitis (2* haemorrhagic colitis, thrombocytopenia purpura, haemolytic uremia syndrome)

21
Q

Escherichia coli treatment

A

treatment don’t treat because will influence more shiga toxin release

22
Q

Haemophilus influenzae virulence factors

A

capsular (not all), catalase, produces beta lactamases

23
Q

Haemophilus influenzae commensal

A

upper resp tract

24
Q

Haemophilus influenzae condition

A

Children meningitis, bronchopneumonia

25
Q

Haemophilus influenzae treatment

A

ceftriazone (cephalosporin)

26
Q

Neisseria meningitidis virulence factors

A

capsule, pilli, lipo-oligosaccharides, IgA protease

27
Q

Neisseria meningitidis commensal

A

10% people nasopharynx

28
Q

Neisseria meningitidis conditions

A

Meningitis and septicaemia

29
Q

Neisseria meningitidis treatment

A

penicillin (beta lactam), and ceftriaxona (cephalosporin)

30
Q

Salmonella virulence factors

31
Q

Salmonella conditions

A

Typhi and paratyphi fever with rose spots and septicaemia. Diarrhoea

32
Q

Salmonella treatments

A

ciprofloxacin (fluoroquinolone)

33
Q

Shigella virulence factors

A

shiga toxin, small infectious dose

34
Q

Shigella conditions

A

mild dysentery

35
Q

Shigella treatment

A

self-limiting (norfloxacin - fluoroquinolone)

36
Q

Yersinia enterocolitica conditions

37
Q

Yersinia enterocolitica treatment

A

self-limiting (norfloxacin - fluoroquinolone)

38
Q

Helicobacter pylori virulence factors

A

lagella, adhesins, urease

39
Q

Helicobacter pylori commensal

40
Q

Helicobacter pylori conditions

A

Peptic ulcers

41
Q

Helicobacter pylori treatment

A

omeprazole (proton pump inhibitor), clarithromycin and amoxicillin

42
Q

Pseudomonas aeruginosa virulence factors

A

Biofilm, catalase oxidase, endotoxin A

43
Q

Pseudomonas aeruginosa commensal

44
Q

Pseudomonas aeruginosa conditions

A

cystic fibrosis colonisation (10+ years). Hospital acquired and ventilator associated pneumonia

45
Q

Pseudomonas aeruginosa initial treatment

A

oral cirpofloxacin and nebuliser antibiotic

46
Q

Pseudomonas aeruginosa more aggressive treatment

A

tobramycin and ticarcillin and clavaunulic acid

I&I (4 decks)

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