Gram +ccoci Flashcards
Enterotoxin have resistant from what?
- faierly heat
- stomach acid
- enzymes in stomach and jejunum
How many immunonlogic types of enterotoxin?
6 A B C D E F
The enterotoxin stimulate…. in GI
Large amount of IL1+IL2 from macrophagesand Th cells
The toxic shock syndome toxib result from
Menstrual….or wound infections or nasal packing that used to to stop bleeding
مين يلي بتصير عندهم اكثر اشي toxic shock syndrome
الناس يلي ما عندهم antibody ضد TSSTجين
Exfoliatinعلى ايش بتاثر وعلى مين اكثر اشي؟
على الskin وبتاثر اكثر اشي young children
بتسببscaleded skin syndrome
What is rhe most important leukocidin ?
1.alpha toxin
((Necrosis of the skin and hemolysis)
2.p_v leukocidin
((Pore-forming toxin that kill cells , esp WBC by damaging cell mem))
What is the cytotoxic effect of the alpha toxin
- Formation of holes in cell.mem
2. loss of low molecular weight substance from damaged cell
الجين يلي بيعمل encoding للp_v leukocidin باي phage?
شو بيعمل هاد الحج؟
كم نسبة البكتريا من نوع الaurus يلي عندها هاد السم
In lysogenic phage بيعمل شغلات شنعه زيه Severe necrotizing pneumonua that caused by S.aureus يلي عندها هاد السم تقريبا ٢%
What is the enzymes that iculde in s.aureus?
- coagulase
- fibrinolysin
- Hyaluronidase
- protease
- nuclease
- lipases
- staphylokinase
شو شغل coagulase
بيعمل clotting plasma وبيحيط بالinfected site وبيمنه وصول الneutrophilلمكان الاصابة
شو الانزيمين يلي بيشتغلو عكس بعض
Coagulase and staphylokinase
الS.aureus وين بتنتقل وبتسبب مرض؟
Skin , soft tissue , bone , joint , lung , heart and kidney.
شو الامراض يلي بتصير في skin and soft tissue
شو سببها
مين اكثر بتسبب hospital ولا community
Impetigo , abcess , cellulitis , folliculitis , conjunctivitis
Post partum breast infection ((mastitis))
سببها الMRSA strains يلي بتنتج p-v leukocidin
Communityاكثر
For TSS is characterized by…..
Fever and hypotension and invovlement of three or more of these organ
Liver,kidney , gi, CNS , muscle or blood
Scalded-skin syndrome is characterized by
fever, large bullae, and an erythematous rash,
large areas of skin slough, serous fluid exudes,
and electrolyte imbalance can occur. (occurs
most often in young children).
S.epudermis ايش بتنتج
وشو اكثر اشي بتسبب
بتنتج الglycocalyx
- Sepsis in neonates
- peritonitis in patients with renal failyre حصوصا الناس يلي بتعمل غسيل لل peritoneal
شو اهمية الglycocalyx للs.epidermis
بتساعد على الالتصاق مع زراعه اي اشي صناعي مش زي لما ينزرع وما يكون على البكتيريا الglycocalyxمش كثير رح ياثر
S.epidermis hospital accqired or community
Hospital
S.saprophyticus is H or C
وين مشهورة
Community
بالuti
Staphylococcus aureus produces a carotenoid pigment called
.
staphyloxanthin, which gives a golden color to its colonies
More than 90% of S. aureus strains contain plasmids that encode
.
a-lactamase, the enzyme that degrades many, but not all, penicillins
Teichoic acids are polymers of ribitol phosphate.
They mediate
adherence of the staphylococci to mucosal cells.
Lipoteichoic acids
play a role in the induction
of septic shock by inducing cytokines such
as interleukin-1 (IL-1) and tumor necrosis factor (TNF) from
macrophages.