Graft vs host disease Flashcards
In which settings does graft vs host disease occur?
Risk factors associated with the developent of graft vs host disease
Primary disorders that can be treated with Hemapoetic stem cell transplantation
Pathogenesis of graft vs host disease
Clinical features of acute GVHD
Clinical staging and histological grading of GVHD
Discuss engraftment syndrome
Diagnostic criteria of engraftment syndrome
Tabulate differences between engraftment syndrome and acute GVHD
Histology of acute GvHD
Discuss the treatment of acute GVHD
Describe the setting in which chronic graft vs host disease occur
Describe the clinical features of chronic GVHD
Reticulate pink – violet papules with scale (lichen planus like) favor dorsal hands, feet, forearms, trunk one form/manifestation
Spectrum of sclerotic involvement
•Lichen –sclerosis like : shiny, wrinkled, gray-white plaques (upper trunk) +- follicular plugging
•Morphea like : localized/widespread indurated, hyperpigmented skin colored plaques. Ulceration
•Eosinophilic fasciitis-like: acute edema/pain, subcutaneous rippling (pseudo cellulite), linear depression following vein between muscle (groove sign) extremities. Hypereosinophilia may be a clue
•Affected nails – brittle/thin/anonychia/pterygium
•Oral/genital mucosa can be affected
•Other sites
•- eyes: keratoconjunctivitis sicca
•-salivary glands: sicca syndrome
•-lungs : bronchiolitis obliterans
•-esophagus : stricture
•-liver
•- pancreas (exocrine insufficiency)
Diagnostic mucocutanoeus criteria of chronic graft vs host disease
Additional diagnostic criteria for chronic graft vs host disease
Tabulate and compare systemic sclerosis and scleroric type of GHVD
Histology of chronic graft vs host disease
Treatment of chronic graft vs host disease
Patient handout/advice with regards to graft vs host disease
Recommendation regarding sunprotection and GVHD
Pictures regarding chronic graft vs host disease
