Graft Rejection Flashcards
How long does a hyper acute infection take?
Minutes after the transplant
what initiates a hyper acute graft rejection?
Humoural immunity (activation of B cells)
What is the treatment of hyperactive graft rejection?
To remove the organ
What effect does a hyper acute graft rejection have on the body?
Causes endothelial damage, inflammation and thrombosis
How long does an acute graft rejection take?
Highest risk is between 1 week and 3 months
What initiates an acute graft response?
T cells
Which organ is at highest risk of acute graft rejection?
The kidney - its highly vascularised
What is the treatment of acute graft rejection?
extensive immunosuppression regiemes
Bone marrow transplant
What effect does acute graft rejection have on the body?
Causes cell damage and interstitial inflammation
How long does chronic graft rejection take?
Months to years
What effects does chronic graft rejection have on the body and the implanted organ?
Fibrosis of blood vessels
long term loss of organ function
smooth muscle proliferation
vessel occlusion
How are chronic graft rejections treated?
With a new transplant
Which medications are used commonly to prevent an organ transplant rejection?
Rapamycin
Cyclosporine
^Inhibit T cell activity
