Grab Bag Flashcards
Methymethacrylate
Bone cement implantation syndrome:
* hypoxia, hypotension
* supportive tx
* anesthesia cannot prevent
* surgeon can lower wash pressure + drill holes
Equation for PaO2 changes with age
PaO2 = 100 - (age/3)
Suspect and TX Bronchospasm
Suspect @ elevated Paw + near induction/extubation + hypoxia
auscultate chest - can be wheeze
Tx:
* 100% FiO2
* albuterol puffs
* deepen with volatile > propofol
* small bolus epinephrine
* ketamine
* magnesium
* terbultaine
causes of post-op polyruia
central DI
nephrogenic DI
SIADH
osmotic - mannitol, glucose
overhydration
Poor R wave progression
LVH
RVH
anterior MI
wnl
Causes of PVC
increase catecholamines @ sugery/anxiety
∆ lytes : hypoK, hypoMg, hyperC
Normal CBF
Ischemic CBF
death CBF
50-55 cc/min/100g
18-20 cc/min/100g
8-10 cc/min/100g
A s/e terbutaline
hypotension
palpitations
CP
pulmonary edema
hypokalemia
hyperglycemia
Treat hemophilia A intraop coagulopathy
(-) VIII
can give VIII but quickly develop abx and become refractory»_space; treat with PCC (has proteases that will breakdown abx, short life) and VIIa (stabilizes downstream coag pathways)
Oligura ddx PRE/INTRA/POST
factor→pre/intra/post:
Usmo→ >500/ <350/∆
UNa→ <10/>10/∆
FeNA → <1/>2%
FeNa formula
FeNa = (Una x Pcr) / (UCr x Pna)
lyte ∆ at CRF
HYPERK, HYPERPO4, HYPERMg
HYPER uric acid, HYPERlipid, HYPERsulphate
hypoNa, hypoCa, hypoalbimin
AG metabolic acidosis
Neuraxial and LMWH/enoxaparin/lovenox ppx qd
HOLD BEFORE NEEDLE: 12 hours
RESTART AFTER NEEDLE: 12 hours
HOLD BEFORE CATH OUT: 12 hours
RESTART AFTER CATH OUT: 4 hours
Neuraxial and LMWH/enoxaparin/lovenox ppx BID
HOLD BEFORE NEEDLE: 12 hours
RESTART AFTER NEEDLE: 12 hours
HOLD BEFORE CATH OUT: remove before starting, do not use this does while catheter in. SPINAL HEMATOMA
RESTART AFTER CATH OUT: 4 hours
Neuraxial and LMWH/enoxaparin/lovenox therapeutic
dose is 1 mg/kg q12 OR 1.5 mg/kg daily
HOLD BEFORE NEEDLE: 24 hours
RESTART AFTER NEEDLE: 24 after non high bleeding risk surgery OR 72 hours after high bleeding risk surgery
HOLD BEFORE CATH OUT: remove before starting, do not dose this way when catheter in SPINAL HEMATOMA
RESTART AFTER CATH OUT: 4 hours
Neuraxial and SQ heparin ppx BID or TID
HOLD BEFORE NEEDLE: 4-6 hours OR check coags
RESTART AFTER NEEDLE: immediately
HOLD BEFORE CATH OUT: 4-6 hours
RESTART AFTER CATH OUT: immediately
Neuraxial and SQ heparin ppx high dose BID or TID
HOLD BEFORE NEEDLE: 12 hours and coags
RESTART AFTER NEEDLE: unknown
HOLD BEFORE CATH OUT: unknown
RESTART AFTER CATH OUT: immediately
Neuraxial and SQ heparin therapeutic
HOLD BEFORE NEEDLE: 24 hours and coags
RESTART AFTER NEEDLE: not recc with catheter in place
HOLD BEFORE CATH OUT: not recc with catheter in palce
RESTART AFTER CATH OUT: immediately
Neuraxial and bypass heparin
HOLD BEFORE NEEDLE: avoid
RESTART AFTER NEEDLE: 60 minutes
HOLD BEFORE CATH OUT: after normal coagulation restored
RESTART AFTER CATH OUT: n/a
Neuraxial and IV heparin
HOLD BEFORE NEEDLE: 4-6 hours and normal coags
RESTART AFTER NEEDLE: 1 hour
HOLD BEFORE CATH OUT: 4-6 hours and normal coags
RESTART AFTER CATH OUT: 1 hour
Neuraxial level @ C/S
T6 hyperbaric
Neuraxial level @ cervical cerclage
T10 hyperbaric
Neuraxial level @ hips
> T12 isobaric
Neuraxial level @ knees
> T12 isobaric
Neuraxial level @ TURP
> T10 of iso or hyperbaric
Treat unstable narrow regular tachycardia
SYNC CARDIOVERT 50-100 J
Treat unstable narrow irregular tachycardia
SYNC CARDIOVERT 120-200 J
Treat unstable wide regular tachycardia
SYNCO 100 J
Treat unstable wide irregular tachycardia
DEFIB 360 J (polymorphic VT)
Mg at torsades
Test dose composition
1.5% lidocaine with 1:200 000 epinephrine
Ekg leads to use intraop
V5 - 75%
V5 + V4 - 90%
V5 + V4 + II - 96%
change of detecting ischaemia
ddx Myasthenic crisis from cholinergic crisis
use edrophonium or tensilon test
MG > weakness will worsen
CC > weakness will improve
Treat cholinergic crisis
supportive w/ possible intubation
d/c anticholinesterase therapy
begin anticholinergics
IVIG
Treat myasthenic crisis
supportive
IVIG
plasmaphoresis
RF in MG for postop mechnical ventilation
- duration of disease > 6 years
- pyridostigmine > 750 mg/day (usually q6h regiment)
- concomitant pulmonary disease
- PIP < -25 cmH2O
- VC < 40 /kg
Extubation criteria: simplified
- hemodynamically stable
- adequately reversed
- awake and alert
- spontaneously ventilating
- VT 6-9 cc/kg
- RR 12-20 with ETCO2 35-40 mmHg
Extubation criteria: detailed
- VC > 15 cc/kg
- pH > 7.3
- PaO2 > 60 mmHg on FiO2 > 50%
- Max NIF > -20
- RR < 30
Treat venous air embolism
Saline onto surgical field
Bone was onto exposed surfaces
aspirate from CVL
gentle compression of IVC
supportive
HSV and neuraxial in pregnancy?
Primary and not treated > contraindicated, possible viremia
Secondary and treated > indicated, low risk viremia
MH vrs thyroid storm
MH: hyperK, rigid, increased CK, lactic acidosis, intraop
Thyroid storm: hypoK, not rigid, no CK, no lactate, postop
Treat MH
dantrolene 2.5 mg/kg
nondepol will not cause paralysis
Treat Thyroid storm
PTU
beta blockers
iodinated contrast
steroids
acetaminophen
reserpine to deplete
Treat neuroleptic syndrome
bromocriptine
+/- dantrolene
stop haldol
nondepol MB will result in flaccid paralysis
Treat serotonin syndrome
cyproheptadine
stop serotonergic meds
drugs dosed by IBW
nondepol NB
drugs dosed by TBW
sux
opioids
propofol gtt
drugs dosed by LBW
propofol induction
TX TURP syndrome
stop irrigation
fluid restriction if Na >120 and symptomatic
hypertonic saline if Na <120
intubated
loop diuretics
benzos for seizures
Nitroprusside toxicity metabolits
cyanomethemoglobin
thiocyanate
cyanide toxicity > MvO2 increases
Tx Nitroprusside toxicity
stop nitroprusside
sodium thiosulfate
inhaled amyl nitrates
hydroxycobalamine
consequences of hyperglycemia
- decreased immune function
- increased oxidative stress
- endothelial dyd
- increased inflammatory factors
- increased procoagulant state
- fluid shifts
- electrolyte ∆
@ surgery - decreased wound healing
- increased infections
- delayed recovery
- end organ failure @ heart, brain, kidney
Sx of hypoglycemia under GA
cant see confusion
maybe diaphoresis
Suspect if concern for light anesthesia = SNS activation
causes of intraoperative hypoK
@ high flow urine (osmotic - mannitol, hyperglycemia OR overhydration, DI, SIADH)
@ excess mineralocorticolides
@ cisplastin/aminoglycosides
@ diuretics
@ vomiting
@ diarrhea
@ alkalemia
Avoid @ IOP
sux
nitrous oxide
ketamine
retrobulbar block
cough
buck
:) @ IOP
decreased IOP
@ volatiles
@ narcotics
@ barbiturates
@ lidocaine
@ nondepolMB
EKG changes from hypoK
flat/inverted T waves
U waves
ST depressions
treat hypoK
replete Mg
replete K
correct alkalemia
stop over diuresis
stop offending drugs
A s/e of hypoK
cardiac hyperrepolarization and excitability
muscle weakness
digoxin toxicity
Max FiO2 on NC
RA ie 21% + 2-3% for each L
max 6 L
max FiO2 35%
Max FiO2 on FM
RA + 2-3% for each L
max 10 L
max FiO2 45%
Drugs to avoid at Pheochromocytoma
avoid tumour stimulation: no sux
avoid SNS stimulation: no ketamine, ephedrine, atropine
avoid histamine release: no sux, morphine, atracurium, cisatracurium
specific to pheo: no metoclopramide, droperidol
weird random drugs to avoid in pheochromocytoma
metoclopramide, droperidol
normal PaO2 on RA
80-100
PaO2 = 100 - (age/3)
SSEP evaluation
- keep anesthesia stabilized
- decreased amplitude, increased latency > talk to surgeon
Describe burst suppression
periods of isoelectricity with slow high voltage wave oscillations
Why burst suppression
neuroprotective
thought to reduce ICP via reduciton of CMRO2 and CBF
Treatment of refractory ICP
barbiturates
decompressive craniotomy
cisatracurium intubating dose
0.15 mg/kg
takes 2 mins onset
lasts 60 mins
Triad for CSWS
hyponatremia
volume contration
low to normal urine osm
Triad for SIAD
hyponatremia
hyperosmolar urine
eu or hypervolemic
Respiratory changes in pregnancy
- mucous capillary engorgement
- MMP 1+ during labour
- aspiration risk
- decreased FRC, ERV
- unchanged TLC bc chest expands
- diaphragm movement not restricted
- compression by fetus
- increased metabolic demand and increased minute ventilation
- rapid onset with volaties
(avoid volatiles after birth > relaxation)
EKG at hyperK
peaked T waves
prolonged PR
flat wave
widened QRS
K for intervention
EKG changes
OR
>6
first EKG usually at 6.5
Result of alkalinization fo local anesthetics
less cations
lipid soluble
can cross membrane easier
more rapid onset
name of syndrome in paralyzed patients that you always forget
autonomic hyperreflexia = loss of descending inhibitory pathways = uninhibited spinal cord reflexes with substantial increased in BP above level of lesions, overzealous vagal response - bradycardia, heart block vasodilation
Level for at risk of autonomic hyperreflexia
T7
Describe response to pain in a paraplyzed patient at level T7 or higher
spinal relexes unchecked by descending inhibitory pathways
Hypertension then exagerrated vagal response - brady, heart block, vasodilation
Celiac plexus block indicatiosn
SNS drive pain T5-T12, pancreatic cancer
S/e celiac plexus block
most common - orthostatic hypotension
second most common - diarrhea
LAST
intrathecal
perforation Ao, IVC, viscera
PTX, chylothorax
paraplegia
postpone surgery for URTI?
postponing for 2 - 3 weeks is reasonable; can have hyperreactivity for up to 8 and icnreased respriatory complications
Preop meds for COPD
bronchodilators
anticholinergics
preop low dose steroids
Steroids periop?
systemic steroids for more than 2 weeks in last six months
induction: 100 mg hydrocortisone
postop: 100 mg q8h for 48 hours.
Principles of anesthetic management for asthmatic patient x3
Block airway reflexes before DL and intubation
Relax airway smooth uscle
prevent release of biochemical mediators
Induce an asthmatic
albuterol
induce with 2.5 mg propofol
oxygen and sevo to deep (iso and des more pungent)
lidocaine
OR
LMA
what NMB to use in asthmatics?
avoid those that cause histamine release: pancuronium, atracurium, sux, mivacurium
USE vec, roc, cisatraciurium
ventilatory mode in COPD
PC > can achieve tidal volumes at lower PIP
increased expiratory time on I:E
may need increased minute ventilation to keep normocarbia
PEEP is controversial > can reduce work of breathing, extrinsic peep shouldnt be more than intrinsic peep, watch out for VR
watch out for autoPEEP
first line treatment for bronchospasm
100% FiO2 and deepen anesthesia b/c most usually due to light anesthesia
pain control to avoi in asthmatics
nsaids
morphine (histamine)
supplemental oxygen and COPD postop
tend to take smaller tial volumes.l
signs and symptoms of hepatopulmonary syndrome
platypnea/dyspnea in upright position
hypoxia PaO2 < 70 on RA
fatigue
digital clubbing
spider angiomata
orthodeoxia - desat upright
cause of hepatorenal syndrome
functional renal vasoconstriction 2/2 splanchnic vasodilation
diagnosis fo hepatorenal syndrome
- cirrhosis with ascites
- serum Cr > 1.5
- no improvement of Cr with 2 days fo diuretic, volume expansion with albumin
- absence of shock
- no nephrotoxic drugs
- no parenchymal kidney disease
- doestn respond to fluid bolus like prerenal
TEST DOSE
3 cc 1.5 % lidocaine with 1:200 000 epinephrine
Dose for labour epidural
bupi 0.0625%+ 0.1% fent at rate of 6 cc/hour with bolus 2-3 cc q20 mins
treat diabetes insipidus
maintainence fluids with D51/2NS and monitor gluc and K
crystalloid for 2/3 last hours UOP
If > 350-400 cc/ hour»_space; DDAVP
Treat MH
stop triggers
increased oxygen flow to 10-15 ppm and FiO2 100
DANTROLENE 2.5 mg/kg q5 min until ETCO2 decreased or temp stops rising
treat hyperK
be prepared to treat arrhythmias
cool
maintain UOP 1-2 cc/kg
ICU for 24 hours with dantrolene 0.25 mg/kg/h and bolus q4-6 hours
hypothyroidism consequences
hyponatremia
hypoglycemia
impaired drug metabolism
clonidine preop
maintain > can have rebound hypertension if stopped
limitations of PULSE OX accuracy
1) no pulse present; low perfusion pressure (hypotension, hypothermia, hypovolemia)
2) hemoglobin variants/dyes
3) severe anemia < 3-4
4) venous pulsation ie RHF and TR
intrathecal morphine dose for c/s
morphine 100 mcg
ex: TCAs
amitriptyline
nortriptyline
ex: SNRIs
duloxetine
fluoxtine
Ex: Anticonvulsants
gabapentin
pregablin
Treat chronic radicular back pain
PT
opiods and NSAIDS
epidural steroid injections
Steroid used for chronic pain epidural steroid injections
methylprednisilone
treat facet syndrome
median branch blocks
(also dxtic)
treat myofascial pain syndrome
massage
needling dry or LA
treat fibromyalgia
SNRI
anticonvulsants
TCAs
support, educate, exercise, CBT
treat diabetic neuropathy
glucose control
anticonvulsants
TCA > SNRI
Treat CRPS
SNS nerve blocks
PT
medication of all sorts
Treat phantom pain
TENS
spinal cord stimulator
biofeedback
Treat cancer pain
appropriate tumour specific neoplastic therapy
WHO ladder
opioids, TCA, SNRI, anticonvulsants, NSAIDs, corticosteroids, oral locals, topicals
interventional (celiac, superior hypogastric, ganglion impar)
behaviour and pscyh
hospice
When to use spc stimulator
intractabel pain of trunks or limbs that fail other management
@ post laminectomy syndrome
@ CRPS
@ neuropathic pain syndrome
@ angina
@ chronic critical limb ischaemia and pain
when to use intrathecal drug delivery
chronic pain w/o response to high dose or unacceptable s/e
PAC indications for the boards
measuring PCWP
CO measurement
mixed venous oxygen saturation measurement
pHTN
pacing
Bucking on the tube
light sedation
pain control inadequate
non paralyzed
treat afib
amiodarone
beta block
CCB
digoxin
electricty
assess hypoV in infants
number of diapers
PO intake
tachycardia
cap refil
fontanelles
cold skin
mottling
cyanosis
altered consciousness
HYPOTENSION IS OMINOUS (35% volume lost before this occurs)
risk factors for airway hyperreactivity with URTIS peds
< 1 year old
smoker in household
bronchopulmonary dysplasia
asthma
epinephrine dose arrest IV peds
0.01-0.03 mg/kg
epinephrine dose arrest ETT peds
0.1 mg/kg
Atropine dose IV peds
0.01-0.02 mg/kg
atropine dose ETT peds
0.3 mg/kg
adenosine peds dose
0.1 mg/kg
max 6 mg
defibrillation peds dose
2-4 Jkg
APGAR score
A - appearance/cyanotic + fingers and toes blue only + pink all over
P - pulse/ none + < 100 + 100-140
G - grimace - none / weak / strong
A - activity - floppy / some flexion / resists extension
R - respirations / none + slow and irregular / strong cry
associated with TEF
VACTERL
veretbral
anal atresia
cardiac
TEF
renal and radial
limb
20% have cardiac
goal for oxygenation in preterm infant
avoid retionopathy
PaO2 50-80 mmHg + SaO2 87-94%
cobb angle values with implications
SCOLIOSIS
> 10 abnormal
> 45-50 surgery
> 60-65 pulmonary dyd
> 70 pHTN at exercise
> 110 pHTN at rest
CO2 laser
corneal injury