Gout, RA Drugs Flashcards
What is generally the 1st line treatment for RA?
1 - Disease-modifying anti-rheumatic drugs (DMARDs)
2 - non-steroidal drugs
3 - aspirin
4 - corticosteroids
1 - Disease-modifying anti-rheumatic drugs (DMARDs)
If a patient has RA and is already on medication. What drugs can be given to help with flare ups?
1 - paracetamol
2 - non-steroidal drugs
3 - aspirin
4 - corticosteroids
2 - non-steroidal drugs
The 1st line treatments for RA are disease-modifying anti-rheumatic drugs (DMARDs). What is the core drug from this list that we need to know?
1 - methotrexate
2 - sulfasalazine
3 - hydroxychloroquine
4 - leflunomide
1 - methotrexate
The 1st line treatments for RA are disease-modifying anti-rheumatic drugs (DMARDs). The core drug is methotrexate, but other drugs include sulfasalazine, hydroxychloroquineand leflunomide. If DMARDs are not successful patients can be prescribed Biologic Agents, such as anti-B, anti-T and anti-TNF-a. How many DMARDs do patients need to have tried prior to being prescribed Biologic Agents?
1 - can go straight to Biologic Agents
2 - >4 drugs
3 - >3 drugs
4 - >2 drugs
4 - >2 drugs
What are the major side effects of Disease Modifying Anti-Rheumatic Drugs?
- bone marrow suppression
- increased risk of infection
- liver dysfunction
There are some drugs that can reduce and some that increase the risk of gout. What 3 drugs/treatments can reduce the risk of gout?
1 - Losartan (BP), Fenofibrate (cholesterol) and vit C 500mg
2 - Losartan (BP), Aspirin and vit C 500mg
3 - Aspirin, Fenofibrate (cholesterol) and vit C 500mg
4 - Thiazide diuretics, Fenofibrate (cholesterol) and vit C 500mg
1 - Losartan (BP), Fenofibrate (cholesterol) and vit C 500mg
There are some drugs that can reduce and some that increase the risk of gout. What 2 drugs can increase the risk of gout?
1 - Losartan (BP) and Fenofibrate (cholesterol)
2 - Losartan (BP) and Aspirin
3 - Aspirin and Thiazide diuretics
4 - Thiazide diuretics, Fenofibrate (cholesterol)
3 - Aspirin and Thiazide diuretics
If a patient presents with an acute gout attack, what medication should be prescribed?
1 - Colchicine and NSAIDs
2 - Colchicine and aspirin
3 - thiazide diuretics and NSAIDS
4 - losartan and NSAIDs
1 - Colchicine and NSAIDs
- Colchicine is a gout specific anti-inflammatory medication
- NSAIDs reduce inflammation, which is common in gout
Colchicine is an anti-gout medication. What is the mechanism of action of this drug?
- inhibits leukocyte migration to joints and phagocytes
- phagocytes attempt to digest, engulf and remove crystals
- instead phagocytes release H+ that can bind with urate anions forming unionised crystals
Although NSAIDs and Colchicine can be used to treat acute gout attacks. Long term medication includes Allopurinol or Febuxostat. What is the mechanisms of action of Allopurinol?
- hypoxanthine is a naturally occurring purine
- hypoxanthine is converted into xanthine by xanthine oxidase
- xanthine is a purine that is converted into uric acid by xanthine oxidase
- ALLOPURINOL INHIBITS xanthine oxidase and reduces uric acid formation
patient should not get gout when on ALLOPURINOL
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD), also called pseudogout is a form of arthritis that causes pain, stiffness, tenderness, redness, warmth and swelling (inflammation) in some joints. What is a conservative management approach?
1 - cold compression and immobilisation
2 - cold compression and steroids
3 - steroids and immobilisation
4 - steroids and NSAIDs
1 - cold compression and immobilisation
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD), also called pseudogout is a form of arthritis that causes pain, stiffness, tenderness, redness, warmth and swelling (inflammation) in some joints. What is treatment for an acute management approach?
1 - cold compression, immobilisation and NSAIDs
2 - cold compression, aspirin and steroids
3 - steroids, colchicine and immobilisation
4 - steroids, colchicine and NSAIDs
4 - steroids, colchicine and NSAIDs
