Gout Drugs Flashcards

1
Q

Probenecid

A

MOA: Inhibits reabsorption of uric acid in proximal
convoluted tubule (also inhibits secretion of
penicillin). Can precipitate uric acid calculi.

Clinical use: chronic gout (preventative)

Adverse effects:

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2
Q

Allopurinol

A

MOA: Competitive inhibitor of xanthine oxidase
–> ↓ conversion of hypoxanthine and xanthine
to urate. Also used in lymphoma and leukemia
to prevent tumor lysis–associated urate
nephropathy. ↑ concentrations of xanthine
oxidase active metabolites, azathioprine, and
6-MP.

Clinical use: chronic gout (preventative)

Adverse effects:

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3
Q

Pegloticase

A

MOA: Recombinant uricase catalyzing uric acid to
allantoin (a more water-soluble product).

Clinical use: chronic gout (preventative)

Adverse effects:

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4
Q

Febuxostat

A

MOA: Inhibits xanthine oxidase.

Clinical use: chronic gout (preventative)

Adverse effects:

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5
Q

NSAIDs

A

Clinical use: acute gout

Any NSAID. Use salicylates with caution (may
decrease uric acid excretion, particularly at
low doses).

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6
Q

Glucocorticoids

A

Oral, intra-articular, or parenteral.

Clinical use: acute gout

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7
Q

Colchicine

A

MOA: Binds and stabilizes tubulin to inhibit
microtubule polymerization, impairing
neutrophil chemotaxis and degranulation.

Clinical use: acute gout; Acute and prophylactic value

Adverse effects: GI,
neuromyopathic side effects.

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