Gout drugs

Question 1

Gout is caused by the overproduction of uric acid or decreased uric acid excretion, or both. This overproduction and/or decreased excretion can often result in?

Answer 1

hyperuricemia

Question 2

Gouty arthritis is the condition in which one or more joints are inflamed due to the collection of gouty deposits inside the joint anatomy. This is also called?
whereas gout that occurs in tissues outside of the joints is called?

Answer 2

articular gout, whereas gout that occurs in tissues outside of the joints is called abarticular gout.

Question 3

Although specific antigout drugs are available, the NSAIDs are considered first-line therapy for most patients with gout.

Answer 3

.

Question 4

The specific antigout drugs—allopurinol, febuxostat, colchicine, probenecid, and sulfinpyrazone—are targeted at the?

Answer 4

underlying defect in uric acid metabolism, which causes either overproduction or underexcretion of uric acid.

Question 5

The new drug febuxostat (Uloric) is a non-purine selective inhibitor of xanthine oxidase. It is the first new drug approved for the treatment of gout since the 1960s. It is more selective for xanthine oxidase than allopurinol. Clinical trials suggest that it may pose a greater risk of?

Answer 5

cardiovascular events than allopurinol, although the mechanism is still being debated. It is not to be given along with theophylline, azathioprine, or mercaptopurine.

Question 6

Antigout drugs are indicated for either?

Answer 6

acute or chronic gout or gout prophylaxis. Diarrhea and abdominal pain are common adverse effects. Antigout drugs are often given to patients during cancer chemotherapy that causes cell death to avoid gout-like syndromes and pain.

Question 7

With antigout drugs, perform a thorough assessment of?

Answer 7

hydration status and baseline serum uric acid levels.

Question 8

If receiving febuxostat (Uloric), assess the patient for a history of?

Answer 8

cardiovascular disease due to the risk of adverse effects linked to the cardiac system.

Question 9

If the patient is taking allopurinol, assess the integrity of the skin due to?

Answer 9

potentially life-threatening skin adverse effects of exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.