Gout Drugs

Question 1

Colchicine

Answer 1

inhibits migration/activation leukocytes. binds tubulin, interferes with function of mitotic spindles. first line, non analgesic, not anti-inflammatory in other disorders. used w/ caution in patients w/ hepatic/renal/CV disease. not for preggers. adverse GI irritation from oral, skin necrosis from IV

Question 2

Allopurinol, Febuxostat

Answer 2

inhibit xanthine oxidase, uric acid synthesis. does not affect acute attack. can be given to compromised renal function, aspirin takers. adverse rash, GI upset

Question 3

Uricosuric agent Sulfinpyrazone

Answer 3

inhibit urate reabsorption. ineffective in aspirin takers. depends on renal function. may cause initial acute attack. does not affect acute attacks. not for patients with blood abnormalities, kidney stones. adverse GI upset, inhibited platelet function, not for hypersensitivity to phenylbutazone

Question 4

Uricosuric agent Probenacid

Answer 4

inhibit urate reabsorption. ineffective in aspirin takers. depends on renal function. may cause initial acute attack. does not affect acute attacks. not for patients with blood abnormalities, kidney stones. adverse GI upset, not for those w/ ulcers, some develop hypersensitivity, overdose CNS issues+death