Gout and Pseudogout

Question 1

What causes raised uric acid?

Answer 1

Diet
Alcohol
Diuretics
Metabolic syndrome
Genetics

Question 2

Which joint is primarily affected by gout?

Answer 2

Metatarcel of big toe

Question 3

What is seen in polarised light microscopy in gout

Answer 3

strongly negatively birefringent needle like crystals

Question 4

What are uric acid levels like during an attack?

Answer 4

Often normal

Question 5

How is an attack managed?

Answer 5

NSAIDs

Question 6

How is gout managed after an attack?

Answer 6

Allopurinol and lifestyle

Question 7

When do you start allopurinol?

Answer 7

1 week after resolved

Question 8

What is more serious complication of gout?

Answer 8

Renal failure

Question 9

What are the crystals in pseudogout?

Answer 9

Calcium pyrophosphate dihydrate

Question 10

What joints normally present in pseudogout?

Answer 10

lower leg or wrist

Question 11

What is seen on Xray in pseudogout?

Answer 11

Chondrocalcinosis

Question 12

What do pseudogout crystals look like on polarised light microscopy?

Answer 12

weakly Positively birefringent rhomboid shaped

Deeply basophillic on H&E staining

Question 13

How is pseudogout managed?

Answer 13

If acute- intra articular steroid injection and NSAIDS and high dose colchicine
low dose NSAIDS used as prevention