Gout Flashcards
1
Q
MOA allopurinol
A
Competitive inhibitor of xanthine oxidase- blocks conversion of hypoxanthine to uric acid
2
Q
MOA febuxostat
A
Non competitive xanthine oxidase inhibitor
3
Q
MOA probenecid
A
Organic acid transport inhibitor that decreases renal uptake of uric acid
4
Q
MOA lesinurad
A
Highly potent inhibitor of renal uric acid reuptake - targets urate transporter URAT1. CI if eGFR <45
5
Q
Risk factor causing gout by increased crystal formation
A
OA