Gout

Question 1

def gout

Answer 1

chronic inflam arthritis d/t the preciptiation and deposition of uric acid crystals (monosodium urate) in and around joints

Question 2

gout in MC in?

Answer 2

males >30Y and postmenopausal women

Question 3

RF of gout

Answer 3

1. fhx
2. drugs (diuretics, aspirin)
3. comorbidities: renal disease, obesity, alcohol
4. metabolic syndrom

Question 4

patho of gout

Answer 4

uric acid is precipitated out into uric acid crystals in the joint space ➔ inflammatory response ➔ swells up and stretches the capsule ➔ red and painful

Question 5

patho of tophi formation

Answer 5

aggregates of MSU form and granulomatous tissue surround it in the case of chronic gout

Question 6

ix for gout

Answer 6

synovial fluid analysis – test for crystals (birefringent)
CBC and CRP - may have elevated WBC and elevated CRP bc inflammation
serum uric acid

Question 7

tx for gout

Answer 7

acute
- colchicine
- NSAIDs - ibuprofen
- intraarticular steroid injections

chronic
- allopurinol (xanthine oxidase inhibitor)
- NSAIDs prn
- wt loss
- pt education of trigger avoidance

Question 8

gout triggers

Answer 8

red meat
fish
organ meat
alcohol
high fructose drinks
dehydration/starvation/trauma
drugs: ASA or diuretics