Gout

Question 1

Gout formation

Answer 1

DNA -> Hypoxanthine -> Xanthine oxidase -> Xanthine -> Xanthine oxidase -> Uric Acid -> Gout

Question 2

Antigout Agents

Answer 2

Allopurinol – to prevent attacks
●Reduces production of uric acid

Colchicine – used for acute attacks
●Reduces inflammatory response to the deposits of urate crystals

Question 3

Allopurinol

Answer 3

Antigout Agent

PREVENTS attacks by blocking production of uric acid. Stops xanthine oxidase.

Question 4

Colchicine

Answer 4

Antigout agent

used for ACUTE attacks

Question 5

Antigout: NSAIDS

Answer 5

Xanthine oxidate inhibitor

Prophylactic use

Question 6

Rheumatoid Arthritis

Answer 6

Systemic disease across the lifespan

●Autoimmune and inflammatory disorder
●attack of synovium
●joint swelling, pain, systemic symptoms
●eventual fusing of bones

Question 7

Antirheumatoid Arthritis Medications

Answer 7

Drugs intended to suppress inflammation
•NSAIDS (symptom relief only)

•DMARDs: Disease Modifying Antirheumatic Drugs
-Slow onset of action (weeks)
-Slows progression of disease

Question 8

disease modifying antirheumatic drugs (DMARDs)

Answer 8

Methotrexate
●most common
●alone or in combination with other drugs

Question 9

Methotrexate

Answer 9

DMARD
Most common

Question 10

Other rheumatoid arthritis drugs

Answer 10

●Glucocorticoids
•Short term use

●Other Immunosuppressant drugs
•gold salts