gout

Question 1

what can cause increased levels of uric acid?

Answer 1

1. increased cell turnover
   lesch-nyhan disease
   myeloproliferative disorders
   diet rich in purines
   exercise
   psoriasis
   cytotoxics
2. reduced renal excretion of uric acid
   drugs- low dose aspirin, diuretics, pyrazinamide
   pre-eclampsia
   alcohol
   renal failure
   lead