Good Laboratory Practice Flashcards

1
Q

What is good laboratory practice?

A

These are a managerial QC system covering the oraganisational process and the conditions under w/c non-clinical health and environmental studies are planned, performed, monitored, recorded, reported, and retained (or archived)

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2
Q

True or False

The process and condition are planned, performed, monitored, recorded, archived, and reported (in good lab practice)

A

True

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3
Q

Good lab practice guarantees what?

A

It guarantees that the data submitted are based on accurate results obtained from the study

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4
Q

What are the things that should be done in terms of promoting and maintaining lab safety?

A

1) Ensure no lab workers will be at risk of getting hurt
2) Use tools properly to reduce equipment-related hazard
3) Ensure that info and procedures are up-to-date
4) Familiarize all equipment and know how to use them properly
5) Properly handle lab equipment and chemicals
6) Instruments must be fully sterilized and cleaned

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5
Q

What are the universal precautions (accdg to OSHA)?

A

1) All human bld and certain human body fluids are treated as if known to be infectious for HIV, HBV, and other bloodborne pathogens
2) These include vigorously washing hands before an intended to prevent parenteral, mucous membrane, and nonintact skin exposures of health-care workers to bldborne pathogens

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6
Q

What are standard precautions (accdg to CDC)?

A

These are the minimum infection prevention practices that apply to all pt care, regardless of suspected / confirmed infection status of the pt, in any setting where health care is delivered

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7
Q

What are the std precautions that should be done?

A

1) Hand hygiene
2) Use of personal protective equipment (PPE)
a. Gloves
b. Masks
c. Eyewear / Eye protection
d. Gowns
e. Face shields
3) Respiratory hygiene / cough etiquette
4) Sharps safety (engineering and work practice controls)
5) Safe injection practices
a. Aseptic technique (for parenteral medications)
6) Sterile instruments and devices
7) Clean and disinfected environmental surfaces

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8
Q

What are the organizations that promote lab safety?

A

1) College of American Pathologists (CAP)
2) Department of Health (DOH)
3) Joint Commission on Accreditation of Healthcare Organizations (JCAHO)
4) National Fire Protection Association (NFPA)
5) Philippine Society of Pathologists (PSP)

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9
Q

What are the different types of hazard?

A

1) Chemical
2) Biological
3) Sharps
4) Radioactive
5) Electrical
6) Physical
7) Fire / Explosive

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10
Q

What are the 2 most dangerous isotopes (under radioactive hazard)?

A

1) Uranium 235

2) Uranium 226

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11
Q

What is chemical hazard?

A

It is any substance that can cause a health problem when ingested / inhaled

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12
Q

What are the exs of chemical hazard?

A

1) Preservatives and rgnts
2) Exposure to:
a. Toxic agents
b. Carcinogenic agents
c. / Caustic agents

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13
Q

What must be done to assess chemical hazard?

A

Avoid getting such materials in / on bodies, clothes, or work area

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14
Q

What are the different hazard classifications? Give their corresponding color

A

1) Health hazard- blue
2) Fire hazard - red
3) Reactivity - yellow
4) Specific hazard - white

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15
Q

What comprises the hazard index?

A

1) 4 - severe hazard
2) 3 - serious hazard
3) 2 - moderate hazard
4) 1 - slight hazard
5) 0 - minimal hazard

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16
Q

What are the personal protection pictograms included in the hazard awareness chart?

A

1) Safety goggles
2) Face shield
3) Apron
4) Dust mask
5) Vapour respirator
6) Self-contained air respirator
7) Gloves
8) Boots
9) Full protection suit
10) No smoking

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17
Q

What are the hazard symbols included in the hazard awareness chart?

A

1) Compressed gas
2) Flammable material
3) Oxidizing
4) Explosion hazard
5) Harmful or Fatal
6) Biohazardous / Infectious
7) Corrosive
8) Health hazard
9) Harmful
10) Harmful to the environment

18
Q

What is biological hazard?

A

These are biological substances that pose a threat to the health of living organisms, primarily that of humans

19
Q

What are the exs of biological hazard?

A

1) Infectious agents
2) Infections
a. Bacterial infections
b. Fungal infections
c. Viral infections
d. Parasitic infections

20
Q

What is the indication of sharp hazard (w/ sign)?

A

Must disposed in punctured-resistant containers and should be conveniently located within the work area

21
Q

What are the exs of radioactive hazard?

A

1) Equipment and radioisotopes

2) Radiation exposure

22
Q

What must be done by persons who are working in a radioactive environment?

A

They are required to wear measuring devices (to determine the amt of radiation they are accumulating)

23
Q

What are the exs of electrical hazard?

A

1) Ungrounded / wet equipment
2) Frayed cords
3) Burns / shock
4) Wet plugs

24
Q

What are the exs of physical hazard?

A

1) Wet floors
2) Heavy boxes
3) Pts
4) Falls
5) Sprains
6) / Strains

25
Q

What are the exs of fire hazard?

A

1) Bunsen burners
2) Organic chemicals
3) Burns / dismemberment

26
Q

What should be done when a fire is discovered?

A

All employees are expected to take the actions in the acronym R.A.C.E and extinguish following P.A.S.S

27
Q

What is the meaning of R.A.C.E?

A

R - rescue
-> rescue anyone in immediate danger
A - alarm
-> activate the institutional fire alarm system
C - contain
-> close all doors to potentially affected areas
E - extinguish / evacuate
-> attempt to extinguish the fire, if possible; exit the area

28
Q

What is the meaning of P.A.S.S (for operating an extinguisher)?

A
P - pull
-> pull the pin
A - aim
-> aim nozzle at base of fire 
S - squeeze
-> squeeze the handle
S - sweep 
-> sweep nozzle side to side
29
Q

What are the details that must bear in mind when operating an extinguisher?

A

1) Know your extinguisher

2) Use the correct extinguisher

30
Q

What are the classes of fire?

A

1) Class A
2) Class B
3) Class C
4) Class D

31
Q

What are the materials involved in Class A (of fire)?

A

Common combustibles

32
Q

What are the materials involved in Class B (of fire)?

A

Flammable liquids and gases

33
Q

What are the materials involved in Class C (of fire)?

A

Live electrical wire

34
Q

What are the materials involved in Class D (of fire)?

A

Combustible metals

35
Q

What are the types of extinguisher that must be used to assess Class A (of fire)?

A

1) Pressurized water

2) Dry chemical

36
Q

What are the types of extinguisher that must be used to assess Class B (of fire)?

A

1) Dry chemical

2) CO2

37
Q

What are the types of extinguisher that must be used to assess Class C (of fire)?

A

1) Dry chemical
2) CO2
3) Halon

38
Q

What are the types of extinguisher that must be used to assess Class D (of fire)?

A

1) Dry chemical

2) Metal X

39
Q

True or False

Good lab practice is not the std framework required to recognize the reliability of scientific companies in the market

A

False, because good lab practice is the std framework required to recognize the reliability of scientific companies in the market

40
Q

True or False

GLP accreditation plays an impt role in boosting the moral of scientists working on highly respected and recognized companies

A

True

41
Q

What is the purpose of GLP implementation?

A

For public benefit and safety

42
Q

True or False

The higher the stds of the GLP is the higher the respect and trust the organization gains

A

True