Gonorrhea Flashcards
What make a strain of Neisseria pathogenic?
virulence factors, they are not all pathogenic
Name the virulence factors of Neisseria:
LOS IgA protease meningococcus capsule gonococcus pili Porins Opa
Neisseria is gram ______, ______cocci, ________ intracellular, aerobic, _________-restricted, oxidase-______, catalase-________, N. meningitidis ferments _______.
positive diplococci facultative intracellular aerobic human-restricted oxidase-positive catalase-positive N. meningitidis ferments maltose
what happens to neisseria when grown on nonselective media?
it gets overgrown by normal flora
it will not grow on blood agar
What kind of media should be used to grow meningitidis?
Thayer-Martin should be used for sampling mucus membrane and chocolate agar should be used for CSF and blood
how does complement deficiency affect neisseria infection?
predisposes to complications
What is the immune response to neisseria? how does it differ between meningococcus and gonococcus?
Host defends with IgG-enhanced complement and PMNs: often effective against meningococcus, usually contains gonococcus
What can asymptomatic or untreated gonococcus lead to in women?
PID
how is N. meninigitidis transmitted?
airborne droplets
T/F: both N. meningitidis and N. gonococcus are encapsulated?
FALSE! only N. meningitidis is encapsulated
Disseminated gonococcal infection and meningococcemia can lead to what complications?
septic arthritis, meningitis, endocarditis
Which is more likely to be sporadic or outbreak: N. meningitidis, or N. gonococcus?
meningitidis is sporadic or outbreak
gonoccocus is common
How does the immune system of a neonate react to meningococcus and gonococcus?
Neonates are protected from meningococcus by maternal passive, must be protected by prophylactic eye ointment from gonococcus
how do you prevent meningococcus and gonococcus?
Vaccine available for meningococcus, condoms for gonococcus
how do you treat neisseria infection?
Treat with ceftriaxone, cefixime, admit if complications
