Goljan Flashcards
What is the MOA of doxorubicin
Doxorubicin acts by hindering DNA replication and transcription by intercalating DNA. It also generates free radicals and inhibits topoisomerase II.
What is the MOA of cyclosporine
Cyclosporine is indicated for prevention of renal, heart and liver transplant rejection and the treatment of RA. Cyclosporin binds to cyclophilin in lymphocytes and this complex inhibits calcineurin, which leads to an inhibition of IL-2 synthesis.
What is the MOA of Basiliximab?
It is a monoclonal ab with high affinity for the IL-2 receptor on activated T cells. This immunosuppressant agent acts by binding to activated lymphocyte IL-2 receptor alpha chains, antagonizing IL-2.
Basiliximab is indicated for kidney transplant rejection prophylaxis and is used with conventional immunosuppressants agents.
Describe First-oder kinetics and how it relates to killing cells?
When applied to the concept of cytotoxicity, means that the drug will kill a constant proportion of tumor cells rather than simply a constant number of cells.
In contrast, zero order kinetics, would result in a constant number of cancer cells being killed per unit of time.
The drug’s half-life does not determine the number of cells killed, assuming an adequate dose is given.
what is the treatment for acute cholecystitis due to an infectious agent?
Cefotaxime and Metronidazole
Acute cholecystitis can be caused by an infection with anaerobic, gram-negative or select gram (+) pathogens.
what is the MOA of Mycophenolate Mofetil
It is covered to the active metabolite mycophenolic acid, which is potent, selective, uncompetitive, and reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH) and thus inhibits de novo synthesis of the guanine nucleotide.
What are the S.E. of Sirolimus?
Sirolimus can cause peripheral edema, hypertension, hypercholesteremia, and hypertriglyceridemia. Other common S.E. include thrombocytopenia and leukopenia.
Other: Atrial fibrillation, heart failure, interstitial pneumonitis, hypervolemia, and palpitations.
What drugs are safe for pregnant women with HTN?
Methyldopa, nifedipine, hydrazine, and labetalol, These drugs are not teratogenic.
