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Biochem > God Send > Flashcards

God Send Flashcards

1
Q

What regulatory mechanism is exemplified by a decrease in activity of an enzyme early in a metabolic pathway by the final product of the pathway

A

Feedback inhibition

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2
Q

Phosphorylation of a eukaryotic initiation factor eIF-2 regulates gene expression by affecting which general process

A

Protein synthesis

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3
Q

Aminoacyl-tRNA synthetases

A

Recognize specific amino acids and specific tRNA’s

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4
Q

Which compound is not directly derived from pyruvate

A

Phosphoenolpyruvate

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5
Q

What two substrates are responsible for the generation of ATP in the payoff phase of glycolysis

A

Phosphoenolpyruvate and 1,3-bisphosphogycerate

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6
Q

Which of the following statements BEST describes allolactose’s role as an inducer of the lac operon

A

A ligand that inactivates the DNA binding capacity of the lac repress or protein

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7
Q

In the liver, which glycolysis enzyme is not a critical point of metabolic regulation in glucose catabolism

A

Phosphoglycerate dephosphorylation of 1,3-bisphosphoglycerate

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8
Q

Glycolysis is an example of which type of metabolic pathway

A

Linear

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9
Q

Which of the following statements about type II restriction endonuclease enzymes is false

A

Many make staggered (off centered) cuts of both DNA strands within their recognition sequences

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10
Q

Which class of nuclei acid serves as an “adapter” for the activation and selection of amine acids used in protein synthesis

A

tRNA

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11
Q

Which component is NOT required in a polymerase chain reaction (PCR)

A

DNA ligase

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12
Q

Which bacterial rRNA, when combined with ribosomal proteins to make the 50S subunit, possesses peptidyl transferase enzyme activity

A

23s

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13
Q

A dietary deficiency of which vitamin involved in oxidation-reductions causes dermatitis among other symptoms

A

Nicotinic acid

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14
Q

Attenuation, or coupled transcription/translation regulation, involves formation of alternative RNA transcript stem-loop structures by directing amino acid abundance. Which of the following amino acid abundance in the attenuation mechanism

A

70s ribosome

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15
Q

In most cases, more than one codon specifies for a single amino acid. This describes the genetic code as being

A

Degenerate

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16
Q

Which of the following eukaryotic RNAP enzymes is unaffected by the mushroom toxin alpha-amanitin

A

RNAP I (most affected is II)

17
Q

What metabolite is oppositely regulated by glucagon and insulin to effect glycolysis or gluconeogenesis

A

Fructose 2,6-bisphosphate

18
Q

Which eukaryotic mRNA post transcriptional process is coordinated by a physical association with the carboxy terminal domain (CTD) of eukaryotic RNAP II

A

All of the above.
5’ cap addition to eukaryotic mRNA, 3’ dnd poly A addition to eukaryotic mRNA, intron removal and exon-exon splicing of eukaryotic mRNA.

19
Q

Which one of the following antibiotics inhibits bacterial translation initiation by interfering with Fmet-tRNA^met, binding to P site of the 30 s ribosome

A

Streptomycin

20
Q

Which nucleotide substrate is post transcriptionally added to the 5’ nucleotide of eukaryotic mRNAs by forming an unusual 5’,5’ triphosphate bond

A

GTP

21
Q

Which elongation factor mimics a changed tRNA and is capable of trans locating a peptidyl-tRNA from the 70s ribosome A site to the P site

A

EF-G-GTP

22
Q

Which of the following enzymes is/are used to compete the 5’ cap structure on eukaryotic mRNAs

A

All of the above
2’-O-methyltransferase, guanine-7-methyltransferase, guanlylytransferase

23
Q

What enzyme isoform in the liver has lower affinity for glucose and helps maintain blood glucose levels

A

Hexokinase IV

24
Q

CAMP binds to cAMP receptor protein (CRP), cAMP-CRP binds to DNA near the lac operon promoter. What type of transcriptional regulator is cAMP-CRP

A

Activator

25
Q

You are given an uncharacterized mRNA nucleotide sequence and asked to find the longest open reading frame using the standard genetic code. The number of potential re…

A

3

26
Q

Which of the following best describes the purpose of the first, or 5’ nucleotide (“wobble”) of a tRNA anticodon

A

Expands the number of mRNA codons a tRNA will recognize

27
Q

After the first “charged” or “activated” tRNA is placed in the appropriate robosomal site for translation, EF-Tu-GTP complex carries all subsequent “charged” tRNAs to which site of the ribosome

A

A site

28
Q

Which glucose transporter is responsible for insulin-dependent uptake of glucose in fat and muscle

A

GLUT4

29
Q

What compound is both a product and an allosteric activator of phosphofructokinase-1

A

AMP

30
Q

The genetic code, or rules by which DNA sequence information is translated into Amino acid sequence, consists of three NT sequence blocks (codons) that…

A

Non-overlapping

31
Q

Which of the following statements about the polymerase chain reaction is FALSE

A

DNA amplification is strictly linear in magnitude with respect to the number of cycles of DNA synthesis

32
Q

The mRNA sequence 5’-GCU ACG UCC-3’ is being translated by a ribosome. Which of the following sets of anticodons represent the three sequential aminoacyl-tRNAs

A

5’-GGA-3’, 5’-CGU-3’, 5’-GCG-3’

33
Q

Which substrate or metabolite has the highest standard free energy of phosphate hydrolysis

A

Phosphoenolpyruvate

34
Q

Deficiency in the ability to convert which monosaccharide from lactose prevents its entry into glycolysis and causes its reduction to a product that causes disease

A

Glucose

35
Q

Which statement is true concerning the Sanger method of DNA sequencing

A

Fluorescent ddNTPs incorporate into the template DNA for detection by sequencing instruments

Biochem (1 decks)

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