GnRH agonists Flashcards
1
Q
Indications for GnRH agonists
A
- to shrink fibroids
2
Q
Side effects of GnRH agonists
A
menopausal symptoms (hot flushes, vaginal dryness) and loss of bone mineral density
3
Q
Examples of GnRH agonists
A
leuprorelin (brand name Lupron) and triptorelin (brand name Decapeptyl), goserelin (zoladex)
4
Q
Mechanism of action GnRH agonists
A
Prolonged activation of GnRH receptors by GnRH leads to desensitization and consequently to suppressed gonadotrophin secretion. This is the primary mechanism of action of agonistic GnRH analogues.
