GN's

Question 1

Non-proliferative (no RBC casts) - Nephrotic

Answer 1

Minimal change
Membranous
FSGS
Paraproteinemia
Pre-eclempsia

Question 2

Proliferative (RBC casts present)

Answer 2

IgA nephropathy (mesangial)
Membranoproliferative
Diffuse proliferative
RPGN
Vasculitis
Familial

Question 3

Minimal change

Answer 3

Causes - lymphoma, NSAIDs

EM - normal glormerulus, diffuse podocytes, foot process fusion, NO deposits

Question 4

Membranous

Answer 4

2o causes: lupus, malignancy, drugs/NSAIDs, hep B
Immune (IgG mediated) deposits - spikes
Capillary loop thickening

Question 5

FSGS

Answer 5

Causes:

- 2o: drugs (heroine, lithium), ureteroreflux, AIDS, decreased mass/hyperfiltration

Question 6

Paraprotein (Amyloid)

Answer 6

Causes:
- 2o: Rheum arthritis (AA amyloid), light chain+/- myeloma (AL amyloid)
EM: proteinaceous deposits, characteristic staining, with congo red/fibrils

Question 7

Diabetes

Answer 7

> 30 mg/day, > 2 mg/mmol, >2.8 mg/mmol

Question 8

Mesangial

Answer 8

Causes 
- 1o: IgA nephropathy, 
- 2o: HSP
Antibodies - normal C3
EM - deposits in the mesangium, proliferation of nucleus

Question 9

Focal Diffuse

Answer 9

Causes: 
- 1o: PIGN - post infectious GN
- 2o SLE
Antibodies - decreases C3/ASOT
Microscopic - pale/swollen cortex, glomerular enlargement, granular loops, subendothelial humps

Question 10

Membranoproliferative

Answer 10

Causes: Hep C

Question 11

Vasculitis

Answer 11

Wegners - c-ANCA (pulmonary disease)

Microscopic polyarteritis - pANCA

Question 12

RPGN

Answer 12

Causes:
- Anti-GBM (Goodpasture), IF: IgG - anti-GBM (linear)
- Familial/Alports (immune complex, ANCA) with decreased GFR,
IF: granular, crescent formation