Glycosaminoglycans

Question 1

Name 2 glycosaminoglycans

Answer 1

Heparin & Heparan Sulfate

Preoteoglycans

Question 2

Glycosaminoglycans are what

Answer 2

linear polymers of repeating disaccharide units

Question 3

One monomer is either what in glycosaminoglycans

Answer 3

N-acetyl-glucosamine

N-acetyl-galactosamine

Question 4

Negatively charged

Answer 4

Uronic acids (C6 Oxidation)
Sulfate esters

Question 5

Extended hydrated molecule does what

Answer 5

Minimizes charge repulsion

Question 6

Glycosaminoglycans form what

Answer 6

meshwork with fibrous proteins to form extracellular matrix

Question 7

Extracellular matrix can be found where

Answer 7

Connective tissue

Lubrication of joints

Question 8

Hyaluronate can be found where

Answer 8

synovial fluid of joints, vitreous humor, cartilage, tendons

Question 9

Chondroitin 4 sulfate can be found where

Answer 9

cartilage, tendons

Question 10

keratan sulfate can be found where

Answer 10

cartilage, horn , hoof, nails and hair

Question 11

Heparin does what

Answer 11

prevents blood clotting

Question 12

Heparin is what polymer

Answer 12

linear

Question 13

Heparan sulfate is what

Answer 13

similar to heparin but attached to proteins

Question 14

How does heparin prevent blood clotting

Answer 14

activating protease inhibitor antithrombin

Question 15

Heparin binds to various cells and regulates what

Answer 15

development and formation of blood vessels

Question 16

Heparan sulfate acts as what

Answer 16

an attachment factor for viruses and bacteria, helping them aggregate tat the surface of cells and find their receptor for infection

Question 17

Plants synthesise what

Answer 17

pectins not glycosaminoglycans

Question 18

Pectins are what type of polysaccharides

Answer 18

hetero

Question 19

Pectins have a core of what

Answer 19

alpha C1 to C4 linked galactruronate residues interspersed with rhamnose