Glycolysis

Question 1

What is glycolysis?

Answer 1

The pathway by which glucose is converted to pyruvate. It occurs in the cytosol of all cells.

Question 2

What happens in the initial reactions? (Phase 1) Prepatory phase

Answer 2

Glucose is phosphorylated and cleaved to form two molecules of the triose glyceraldehyde-3- phosphate. This requires the expenditure of two ATPs in an “energy investment”

Question 3

What happens in the second phase? ( Payoff phase)

Answer 3

The two molecules of glyceraldehyde 3-3 phosphate are converted to pyruvate with the concomitant generation of four ATPs.

Question 4

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Answer 4

1. Hexose is phosphorylated twice by ATP and then cleaved to yield two triose phosphates.
2. Fructose-6-phosphate is phosphorylated (

Question 5

What is the importance of Phosphorylated intermediates?

Answer 5

1. Lacks transporters for phosphorylated sugars

2. Phosphoryl groups are essential components in the enzymatic conservation of metabolic energy

Question 6

Prepatoryphase enzymes:

Answer 6

1. Hexokinase
2. Phosphohexose isomerase
3. Phosphofructokinase-1
4. Aldolase
5. Triose phosphate isomerase