Glycolysis

Question 1

Site of glycolysis

Answer 1

Cytoplasm

Question 2

Deficiency of this enzyme causes decreased muscular performance and fatigue

Answer 2

PFK I

Question 3

Cleaves furctose 1,6-bisphosphate into GADP and DHAP

Answer 3

Aldolase A

Question 4

Cleaves fuctose 1-phosphate into glyceraldehyde and dihydroacetone phosphate

Answer 4

Aldolase B

Question 5

Aldolase enzyme most common in most cells

Answer 5

Aldolase A

Question 6

Aldolase enzyme present in liver and kidney

Answer 6

Aldolase B

Question 7

Agents that inhibit glyceraldehyde 3-phosphate dehydrogenase via inhibition of formation of thiohemiacetal

Answer 7

Sulfhydryl reagents

Question 8

Inhibitor of glycosus as it promotes overproduction of reactive O2 species which also leads to non-formation of a thiohemiacetal

Answer 8

Hyperglycemia

Question 9

Inhibitor of glycolysus which prevents synthesis of ATP by competing with the Pi binding site

Answer 9

Arsenate

Question 10

The reduction of pyruvate to L lactate in the absence of O2 is coupled with the

Answer 10

Reoxidation of NADH to NAD+

Question 11

Inhibits glycolysis by inhibiting enolase

Answer 11

Fluoride

Question 12

Deficiency in pyruvate kinase, there is also decreased ATP synthesis in

Answer 12

RBCs –> alteration of shape –> increased phagocytic activity that engulf damaged RBCs –> premature death of RBCs –> hemolytic anemia

Question 13

Deficient PFK results in

Answer 13

fatigue, low exercise tolerance