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Metabolisme > glycolyse en gluconeogenese > Flashcards

glycolyse en gluconeogenese Flashcards

1
Q

allosterische controle (spier) PHOSPHOFRUCTOKINASE

A

(-) ATP
(-) H+
(+) AMP

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2
Q

allosterische controle (spier) HEXOKINASE

A

(-) GLU-6-P

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3
Q

allosterische controle (spier) PYRUVAATKINASE

A

(-) ATP

(+) F-1,6-BP

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4
Q

allosterische controle (spier) PYRUVAAT CARBOXYLASE

A

(-) ADP

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5
Q

allosterische controle (spier) PHOSPOENOLPYRUVAAT CARBOXY KINASE

A

(-) ADP

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6
Q

allosterische controle (spier) FRUCTOSE-1,6-BIPHOSPATHASE

A

(-) AMP

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7
Q

glycolyse gluconeogenese SPIER

A

afhankelijk van energie charge ATP/AMP

-hoog = veel ATP = daling GLYCOLYSE & stijging GLUCONEOGENESE

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8
Q

glycolyse gluconeogenese LEVER

A
  • Aanwezigheid van bouwstenen biosynthese
  • hoog = daling GLYCOLYSE & stijging GLUCONEOGENESE
  • glucose concentratie in bloed
  • hoog (insuline) = stijging GLYCOLYSE & daling GLUCONEOGENESE
  • laag (glucagon) = daling GLYCOLYSE & stijging GLUCONEOGENESE
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9
Q

allosterische controle (lever) PHOSPHOFRUCTOKINASE

A

(-) ATP
(-) citraat
(+)

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10
Q

allosterische controle (lever) HEXOKINASE

A

(-) Glu-6-P

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11
Q

allosterische controle (lever) GLUCOKINASE

A

heeft er geen

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12
Q

allosterische controle (lever) PYRUVAATKINASE

A

(-) ATP
(-) Alanine
(+) F-1,6-BP

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13
Q

allosterische controle (lever) PYRUVAAT CARBOXYLASE

A

(-) ADP

(+) acetyl-coA

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14
Q

allosterische controle (lever) PHOSPOENOLPYRUVAAT CARBOXY KINASE

A

(-) ADP

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15
Q

allosterische controle (lever) FRUCTOSE-1,6-BIPHOSPATHASE

A

(-) AMP
(-) F-2,6-BP
(+) citraat

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16
Q

COVALENTE MODIFCIATIE LEVER

glucose in bloed = LAAG

A
  1. Vrijstelling glucagon
  2. activatie PKA
  3. Fosforylatie PFK2–> inactivatie
  4. Activatie FBPase2
  5. [F-2,6-BP] daalt –> [F-6-P] stijgt -(isomerase)-> G-6-P -(G6pase)-> glucose
  6. Glycolyse daalt & Gluconeogenese stijgt
    * fosforylatie pyruvaat kinase: phospoenolpyruvaat -x-> pyruvaat
17
Q

COVALENTE MODIFCIATIE LEVER

glucose in bloed = HOOG

A
  1. Vrijstelling insuline
  2. Activatie PP (protein phosphatase) via tyrosine kinase receptor
  3. Defosforylatie PFK2–> activatie
  4. Inactivatie FBPase2
  5. [F-2,6-BP] stijgt–> [F-6-P] daalt -(isomerase)-> G-6-P -(G6pase)-> glucose
  6. Glycolyse stijgt & Gluconeogenese daalt
    * defosforylatie pyruvaat kinase: phospoenolpyruvaat –> pyruvaat
18
Q

REGULATIE ENZYMHOEVEELHEID LEVER

glucose in bloed = LAAG –> Glucagon

A
  1. Daling TRANSCRIPTIE
  2. PFK1 daalt
  3. PK daalt
  4. PFK2/FBPase2 daalt
    => GLUCONEOGENSE stijgt & GLYCOLYSE daalt
19
Q

REGULATIE ENZYMHOEVEELHEID LEVER

glucose in bloed = HOOG –> Insuline

A
  1. Stijging TRANSCRIPTIE
  2. PFK1 stijgt
  3. PK stijgt
  4. PFK2/FBPase2 stijgt
    => GLUCONEOGENSE daalt & GLYCOLYSE stijgt
20
Q

Cori cyclus

A

Lactaat (spier) –> bloedbaan –> lever –> pyruvaat –> glucose –> bloedbaan –> spier –> pyruvaat –> lactaat

Metabolisme (1 decks)

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