Glycaemic Control Flashcards
List the rapid acting analogues
Humalog
Apidra
Novorapid
List the short acting analogues
Acts Hastily
Actrapid
Humulin S (short)
List Intermediate analogues
Intermediate Hyperglycaemic Intervention
Insulatard
Humulin I
Insuman basal
Long acting analogues
Long Long Time
Lantus
Levemir
Tresiba
Difference between pre-mixed regular and analogue?
Regular: Comb OR M3
analogue: Mix
How often do you review insulin for adjustment?
Every 48 hours
DONT OMIT IT
For basal-bolus, how do you manage…
Recurrent hyperglycaemia
Unexplained hypoglycaemia
Increase/Reduce dose prior to episode by 2-4 units (eg morning reading, alter nightime) for hyper/hypo respectively
How do you alter the following regimens in recurrent hyperglycaemia/hypoglycaemia
Basal bolus
Twice daily mixed analogues
Long-acting analogues +/- oral hypoglycaemics
General:
Increase/reduce the dose prior to the reading* time by 2-4 units (breakfast reading –> alter nightime dose)*
Long acting:
Fasting hyperglycaemia: Increase 2-4 units
Non-fasting hyperglycaemia: Consider short acting at mealtimes
In T2DM, what is the typical first line?
Metformin
What should be checked prior to metformin prescription?
Baseline eGFR
<45: Reduce dose
<30: Contraindicated
What are the common side effects of metformin and how are they managed?
GI upset: trial MR form
Lactic acidosis: stop and seek advice
What are the alternatives to metformin?
DPP-4Is (gliptins)
Sulfonylureas (gliciazide)
SGLT-2Is (flozins)
Pioglitazone (can be problematic tho)
What is step up treatment following first line
2nd line: + another agent
3rd line: + 3rd agent OR commence insulin
What is a basal-bolus regimen
Long acting insulin + Rapid/Short acting insulin
When is VRIII considered?