Glucose-6-phosphatase dehydrogenase deficiency Flashcards
Glucose-6-phosphatase deficiency is a rare genetic disorder that is characterised by low levels of Glucose-6-phosphatase. Does this typically result in hypoglycaemia or hyperglycaemia?
- hypoglycaemia
What is the incidence of Glucose-6-phosphatase deficiency?
1 - 1:100,000
2 - 1:10,000
3 - 1:1000
4 - 1:100
1 - 1:100,000
Glucose-6-phosphatase deficiency is a rare inborn genetic mutation. However, which population have a much higher incidence of 1:20,000 when compared to the current 1:100,000?
1 - south east asians
2 - ashkenazi Jews
3 - caribbean
4 - finish
2 - ashkenazi Jews
The human body naturally produced free radicals, such as hydrogen peroxidase, which in high levels can damage tissues including DNA, proteins and the cell membrane. However, the body is able to produce what that is able to neutralise these free radicals?
1 - glutathione
2 - glutamine
3 - glutamate
4 - glucose-6-phosphotase
1 - glutathione
In order for glutathione to be able to neutralise free radicals it must be in the reduces state so that they can donate what to neutralise the free radicals?
1 - NADH
2 - electron
3 - NAD
4 - ATP
2 - electron
- 2H2O2 (hydrogen peroxidase is then converted into H2O and O2
Once glutathione has donated an electron to neutralise free radicals it becomes oxidised (lose an electron). What does it need so it can become reduced (gain an electron)?
1 - NADH
2 - cGMP
3 - NAD
4 - ATP
1 - NADH
- enzyme glutathione reductase takes electron from NADH, which then becomes NADPH and then NADP+
Once glutathione reductase takes electron from NADH and transfers it to glutathione so it can become reduced again, the NADH becomes NADP+. Which enzyme is then responsible for converting NADP+ back into NADH?
1 - glutathione oxidase
2 - HMG-CoA reductase
3 - hexokinase
4 - glucose-6-phosphatase dehydrogenase
4 - glucose-6-phosphatase dehydrogenase
