gluconeogenesis and glucose homeostasis

Question 1

gluconeogenesis

Answer 1

the synthesis of glucose from non-carbohydrate precursors e.g. lactate, AAs [alanine], glycerol [triacylglycerols]

Question 2

glucose requirements

Answer 2

• brain and red blood cells require glucose as a fuel.
• daily requirement=160g
• glycogen stores=190g
• therefore glycogen stores have enough glucose to last ~ 1 day

Question 3

gluconeogenesis pathway

Answer 3

reversal of glycolysis except for 3 steps:

1) pyruvate to PEP
2) F1,6BP to F6P
3) G6P to glucose.

these steps are irreversible in glycolysis, so require different enzymes and energy inputs.