Gluconeogenesis Flashcards
1
Q
What is gluconeogenesis?
A
11 step pathway that converts non-carbohydrate precursor molecules into intermediates where they ultimately become glucose
2
Q
When does gluconeogenesis occur?
A
when dietary sources of glucose are unavailable and when the liver has depleted stores of glycogen
3
Q
Where does gluconeogenesis occur?
A
primarily in the liver, sometimes in the kidney
4
Q
What enzyme runs the first step of gluconeogenesis?
A
pyruvate carboxylase
5
Q
What enzyme runs the second step of gluconeogenesis?
A
phosphoenolpyruvate carboxykinase (PEPCK)
6
Q
Which intermediate cannot be used in gluconeogenesis?
A
acetyl-CoA
7
Q
Why does glu-6-P need to be desphosphorylated at the end of gluconeogenesis?
A
it is charged in that state and cannot cross into the bloodstream
