Gluconeogenesis Flashcards
How is pyruvate produced in gluconeogenesis?
from lactate by lactate dehydrogenase
from some amino acids
How is oxaloacetate produced in gluconeogenesis?
from some amino acids directly
or
lactate/amino acids to pyruvate to oxaloacetate
How is DHAP produced in gluconeogenesis?
glycerol backbone
source of amino acids
diet
breakdown of skeletal muscles
What is converted directly to glycogen?
glucose-6-phosphate
What is a good source of NADPH for anabolic pathways?
Amino acid production via pentose phosphate from glucose 6 phosphate
when does the body enter hypoglycaemic coma?
when plasma levels fall below 3mM
which reactions of glycolysis are irreversible?
reactions by hexokinase, phosphofructokinase and pyruvate kinase
delta G for straight glycolysis removal
90kJ.mol or loss of 6 ATP
Which enzyme catalyses the conversion of pyruvate to oxaloacetate?
pyruvate carboxylase
Which enzyme catalyses the conversion of oxaloacetate to phosphoenolpyruvate?
phosphoenolpyruvate carboxykinase
Which enzyme catalyses the conversion of fructose 1,6 diphosphate to fructose 6 phosphate?
fructose 1,6 biphosphatase
Which enzyme catalyses the conversion of glucose-6-phosphate to glucose?
Hexokinase
What is the del G for gluconeogenesis?
-38kJ/mol
