Glucocorticoids

Question 1

1,2 double bond

Answer 1

Five-fold enhancement in GR/MR ratio

Question 2

6ɑ - CH3 or F

Answer 2

Enhances GR/MR ratio

Question 3

9ɑ - F or Cl

Answer 3

Enhances GR and MR potency

Question 4

16ɑ or β - CH3 or O

Answer 4

Decreases MR activity

Question 5

17ɑ - O

Answer 5

Required for GR activity; can be part of acetonide ring or ester

Question 6

21 - OH, F or Cl

Answer 6

Required for GR/MR activity; ester prodrug must be hydrolyzed to OH for maximum activity

Question 7

11β - OH

Answer 7

Required for full GR/MR activity; more important for GR