Glucagon

Question 1

Glucagon dosing for βB/CCB overdose?

Answer 1

2-10 mg Bolus q 10-15 minutes

2 - 5 mg/hr infusion titrated to hemodynamic response

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Question 2

Glucagon dosing for GI relaxation?

Answer 2

0.25 - 0.5 mg (2mg Max) IV

2mg IM

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Question 3

Glucagon dosing for Anaphylaxis for pts on β-blockers?

Answer 3

1 - 5mg Bolus
Followed by
5 - 15 mcg/min infusion titrated to hemodynamic response

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Question 4

Glucagon dosing for Hypoglycemia

Answer 4

1 mg q 15 min

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Question 5

Glucagon MoA for Hypoglycemia

Answer 5

• Binds to glucagon receptors (G-protein linked) on liver hepatocytes
• Stimulates Adenylate cyclase → ↑ cAMP → ↑ glycogenolysis/gluconeogenesis

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Question 6

Glucagon MoA for βB/CCB overdose

Answer 6

• Binds to glucagon receptors (G-protein linked) on SA/AV nodes & cardiac myocytes (bypassing β blockade)
• Stimulates Adenylate cyclase → ↑ cAMP → ↑ calcium release
• ↑ Inotropy/Chronotropy

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Question 7

IV Glucagon onset-> peak

Answer 7

5-20 minutes

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Question 8

Metabolism/Elimination of Glucagon?

Answer 8

Metabolism: Liver, Plasma, Renal
Elimination: Renal/Bile

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