Glomerulonephritis Flashcards
what does damage to endothelial or mesangial cells lead to
proliferative lesion and red cells in urine
does damage to podocytes lead to a proliferative or a non-proliferative lesion
non-proliferative
does damage to podocytes lead to protein in the urine or red cells in the urine?
protein
microalbuminuria range
30-300mg albuminuria/day
asymptomatic proteinuria value
< 1g/day
heavy proteinuria range
1-3g/day
nephrotic syndrome value
proteinuria >3g/day
what bit of the glomerulus does nephrotic syndrome affect
podocytes
what is the renal function usually like in nephrotic syndrome
normal
what would minimal change disease look like on light microscopy
pretty normal
what are the treatment principles of glomerulonephritis
- reduce degree of proteinuria
- induce remission of nephrotic syndrome
- preserve longterm renal function
non-immunosuppressive treatment of glomerulonephritis
- anti-hypertensives
- ACEi/ARB
- SGLT2i
- Diuretics
- Statins
- Anticoagulants in nephrotic syndrome with profound hypoalbuminaemia
what are the main types of glomerulonephritis
- minimal change
- focal segmental glomerulosclerosis
- membranous nephropathy
- membranoproliferative
- IgA nephropathy
what is the most common type of glomerulonephritis
IgA nephropathy
what would you find on renal biopsy in a patient with IgA nephropathy
Mesangial cell proliferation and expansion on light microscopy with IgA deposits in mesangium on IF
