Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

CLIN MED3: GU/Renal > Glomerular DO > Flashcards

Glomerular DO Flashcards

1
Q

what is glomerular disease

A

any process that causes damage to glomerulus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is tubulointertititial disease

A

any process that casues damage to the interstitital tissues or tubules
(everything but glomerulus and capillaries)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is AIN

A

acute interstitial nephritis (aka acute tubulointertitial nephritis or ATIN)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the presentation of chronic tubulointerstitial nephritis

A

obstructive, vesicoureteral reflux, analgesic nephropathy, heavy metals, myeloma kidney

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the causes of ATIN

A

medications #1 cause
RSVP: rifampin, sulfa, and 5 Ps
(PPI, Pain killers (nsaids), Pee pills (diuretics), penicillin and phenytoin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the classic triad of ATIN

A

fever, rash, arthralgia
often with oliguira

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is seen on labs with ATIN

A

often with eosinophilia
pyuria
proteinuria
microscopic hematuria
renal tubular epithelial cell casts or granular casts
WBC casts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is the definitive diagnostic test for ATIN

A

kidney biopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what patients get biopsy with ATIN

A

no improvement when agent discontinued
diagnosis is unclear
progressive kidney dysfunction
im considering steroids
its early disease and thus unclear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the treatment of ATIN

A

stop offending drug
supportive (BP control, tx anemiiuas, fluids)
Maybe steroid if persistent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the prognosis of ATIN

A

recovery of kidney function in 6-8 weeks, but not always to baseline
risk of progression to CKD
prognosis worst with NSAID induced AIN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is the hallmark of glomerular diseases

A

proteinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what are the classifications of glomerular disease

A

nephritic or nephrotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is nephritic

A

‘less severe’
proteinuria < 3g/day
hematuria
RBC casts
edema, hypertension, oliguira
labs: elevated Scr, decreased GFR, increased BUN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is nephrotic

A

‘more severe’
proteinuria >3g/day
edema
hypoalbuminemia
hyperlipidemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is the primary presenting sign on physical exam for glomerular disease

A

edema
acute GFR reduction - hypernatremia - edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what is the workup for glomerular disease

A

CBC (eosinophilia)
albumin level
BMP (kidney and sodium)
urinalysis
proteinuria (24 hour collection or spot urine protein:creatinine ratio)

18
Q

What is the definitive test for glomerular disease

A

kidney biopsy

19
Q

what is post-infectious glomerulonephritis, nephritic or nephrotic

A

nephritic

20
Q

what is Henoch Schonlein Purpura (HSP)

A

acute, immune-mediated (IgA), small vessel vasculitis
90% of cases in kids < 10 years old

21
Q

if a patient with post-infectious GN presents with palpable purpura on LEs/buttocks what are you thinking

A

Henoch Schonlein Purpura (HSP)

22
Q

what is the most common nephritic syndrome

Kids and yonger adults (20-30s)

A

IgA Nephropathy

23
Q

What is thetreatment of post-infectious GN

A

Self-limiting, treat infection

24
Q

What is the treatment of Anti-GBM GN

A

plasma exchange + steroids + cyclophosphamide

25
Q

what is the diagnosis of choice for Anti=GBM GN

A

biopsy: crescent formation and linear IgG deposition inthe basement membrane

26
Q

what is the patho of idiopathic membranoproliferative GN

A

thickening and splitting onf the BM (tram track appearance)

27
Q

what is the pathophysiology of diffuse proliferative GN

A

increased glomerular cellularity, thickening of MG capillaries, IgG and C3 deposits
most common SLE manifestation

28
Q

what is the classic presentation of HSP

A

palpable purpura
arthritis
abdominal pain
renal disease (GN)

29
Q

What is the treatment of HSP

A

supportive treatment, usually resolves on its own
can use steroids

30
Q

what is the treatment of NST

A

supportive treatments
diuresis if necessary
pts without AKI - ACEI/ARB for anti-proteinuric and HTN tx
if AKI - dialysis
if inflam - steroids

31
Q

what are the nephrotic syndromes

there are three

A

Minimal change disease
focal and segmental Glomerulosclerosis
membranous nephropathy

32
Q

what is the most common nephrotic syndrome in kids

A

minimal change disease

33
Q

what is the most common nephrotic syndrome in adults

A

focal or segmental glomerulosclerosis

34
Q

what is the treatment on minimal change disease

A

steroids until proteinuria resolves
should resolve in 4-8 weeks

35
Q

What is the treatment of focal and segemental glomerulosclerosis

A

corticosteroids (more likely to fail tx)
if fail - immunosuppressant or ACEI/ARB

36
Q

what is the treatment of membranous nephropathy

A

ACEI/ARB and corticosteroids
if fail, add immunosuppressant

37
Q

what is the general treatment for nephrotic syndromes

A

sodium restriction
fluid restriction
diuresis

38
Q

when are complications more likely

A

Nephrotic syndrome (more severe)

39
Q

what is the most ocommon complication of nephrotic syndrome

A

VTE

40
Q
A

CLIN MED3: GU/Renal (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions