GLOMERULAR DISORDERS

Question 1

Deposition of immune complex, formed in conjunction of Group A
Streptococcus (Streptococcus pyogenes)

Answer 1

Acute Post-streptococcal Glomerulonephritis

Question 2

Deposition of immune complexes from systemic immune disorders
(ex: SLE) on the glomerular membrane

Answer 2

Rapidly Progressive (Crescentic) Glomerulonephritis

Question 3

Deposition of antig-lomerular basement membrane antibody to
glomerular and alveolar basement membranes

Answer 3

Goodpasture Syndrome

Question 4

Anti-neutrophilic cytoplasmic auto-antibody (ANCA) binds to
neutrophils in vascular walls producing damage to small vessels in the
lungs and glomerulus

Answer 4

Wegener’s Granulomatosis

Question 5

Occurs in children following viral respiratory infections; Decrease in platelets disrupts vascular integrity

Answer 5

Henoch Schonlein Purpura

Question 6

Thickening of glomerular membrane following IgG immune complex
deposition associated with systemic disorders

Answer 6

Membranous Glomerulonephritis

Question 7

‘Cellular proliferation affecting the capillary walls or the glomerular
basement membrane, possibly immune mediated

Answer 7

Membranoproliferative Glomerulonephritis

Question 8

Marked decrease in renal function resulting from glomerular
damage precipitated by other renal disorders

Answer 8

Chronic Glomerulonephritis

Question 9

Deposition of IgA on the glomerular membrane resulting from
increased levels of IgA

Answer 9

IgA Nephropathy (Berger’s Disease)

Question 10

Little cellular changes in the glomerulus;Disruption of podocytes primarily in children following
aliergic reactions & immunizations

Answer 10

Minimal Change Disease (Nil Disease/Lipoid Nephritis)

Question 11

Disruption of podocytes in certain numbers and areas o glomeruli,
others remain normal

Answer 11

Focal Segmental Glomerulosclerosis

Question 12

Most common cause of ESRD; Deposition of glycosylated proteins on the glomerular basement membranes caused by poorly controlled blood glucose levels

Answer 12

Diabetic Nephropathy (Kimmelstiel-Wilson Disease)

Question 13

Genetic disorder showing lamellated and thinning of glomerular
basement membrane

Answer 13

Alport Syndrome

Question 14

Disruption of the electrical charges that produce the tightly fitting
podocyte barrier resulting to massive loss of proteins and lipids

Answer 14

Nephrotic Syndrome