Glomerular Diseases Flashcards

1
Q

Mutation in this gene causes FSGS in adulthood

A

TRPC6

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2
Q

Gross hematuria may be seen in

A

IgA nephropathy

Sickle cell diease

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3
Q

Pathologic equivalent of the clinical presentation of RPGN

A

Cresentic Glomerulonephritis

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4
Q

Renal Biopsy in Poststreptoccal Glomerulonephritis

A

Hypercellularity of mesangial and endothelial cells
Glomerular infiltrates of PMN
Granular deposits of IgG, IgM, C3, c4, c5-9
Subepithelial deposits “humps”

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5
Q

Classic Presentation of Post Streptococcal Glomerulonephritis

A
Hematuria
Pyuria
Red blood cell casts 
Edema 
Hypertension
Oliguric renal failure
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6
Q

Most common clinical sign of renal disease in Lupus Nephritis

A

Proteinuria

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7
Q

Class I Lupus Nephritis

A

Normal Glomerular Histology by any technique or normal light microscopy with minimal mesangial deposits on electron microscope

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8
Q

Class II Lupus Nephritis

A

Mesangial Immune complexes with mesangial PROLIFERATION

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9
Q

Class III lupus Nephritis

A

Focal Nephritis

Focal endocapillary with extracapillary proliferation with focal subendothelial immune deposits and mesangial expansions

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10
Q

Class IV Nephritis

A

Diffuse nephritis
Diffuse endocapillary with =/w/o extracapillary proliferation with diffuse subendothelial immune deposits and mesangial alterations

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11
Q

Class V

A

Membranous nephritis

Thickened basement membrane with diffuse subepithelial immune deposits

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12
Q

Class VI

A

Sclerotic nephritis

Global sclerosis of nearly all glomerular capillaries

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13
Q

Pulmonary renal syndrome presents as lung hemorrhage and glomerulonephritis involving collagen IV (alpha 3NC1 domain)

A

Goodpasture syndrome

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14
Q

HSP is different from IgA nephropathy in that

A

there is prominent systemic symptoms, younger age (<20 years old), preceding infection and abdominal complaints

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15
Q

2 most common presentation of IgA nephropathy

A
  1. Recurrent episodes of Macroscopic hematuria during or immediately following an upper respiratory infection often accompanied by proteinuria
  2. Persistent asymptomatic microscopic hematuria
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16
Q

Treatment of IgA nephropathy

A
No consensus 
ACE inhibitors
Tonsillectomy
Steroid therapy
Fish oil
17
Q

What are the two types of antibodies of ANCA small vessel vasculitis

A

Anti-proteinase 3 (PR3)

anti-myeloperoxidase (MPO)

18
Q

Clinical Presentation of Granulomatosis with Polyangiitis

A

Fever, Purulent rhinorrhea, nasal ulcers, sinus pain, polyarthralgia/arthritis, cough, hemoptysis, shortness of breath, microscopic hematuria
0.5-1 g/24 hr proteinuria

19
Q

Difference between Microscopic Polyangiitis and Granulomatosis with Polyangiitis

A

absence of granulomas in vasculitis in microscopic polyangiitis

20
Q

Small vessel vasculitis

peripheral eosinophilia, cutaneous purpura, mononeuritis, asthma, allergic rhinitis

A

Churg Strauss Syndrome

21
Q

Type of MPGN commonly associated persistent hepatitis C infection, autoimmune disease with note of tram-tracking

A

TYPE I MPGN

22
Q

Classical Presentation of Nephrotic Syndrome

A
Heavy Proteinuria, minimal hematuria
Hypoalbuminemia
Hypercholesterolemia
Edema 
Hypertension
23
Q

Presentation of FSGS

A

hematuria
Hypertension
any level of proteinuria

24
Q

Factors associated with poor outcome in FSGS

A

African american
Nephrotic range proteinuriia
Renal insufficiency

25
Q

Secondary causes of FSGS

A
Viruses: HIV/Hepatitis B/Parvovirus
Hypertensive nephropathy 
Reflux nephropathy 
Cholesterol emboli
Drugs: Heroin/Analgesics/Pamidronate
Oligomenaphronia
Renal dysgeneis
Alport syndrome 
Sickle cell disease
Lymphoma
Radiation nephritis
26
Q

Associated diseases with Membranous Glomerulonephritis

A

malignancy (solid tumors of the breast, lung, colon)
Infection ( Hepatitis B, Malaria, schistosomiasis)
Rheumatologic disorders ( SLE, RA)

27
Q

Subepithelial deposits

A

Membranous Glomerulonephritis

28
Q

Acute nephritic picture

A
Hematuria
Pyuria
Red blood cell casts
Edema
Hypertension
Oliguric renal failure