Glomerular Diseases Flashcards
Mutation in this gene causes FSGS in adulthood
TRPC6
Gross hematuria may be seen in
IgA nephropathy
Sickle cell diease
Pathologic equivalent of the clinical presentation of RPGN
Cresentic Glomerulonephritis
Renal Biopsy in Poststreptoccal Glomerulonephritis
Hypercellularity of mesangial and endothelial cells
Glomerular infiltrates of PMN
Granular deposits of IgG, IgM, C3, c4, c5-9
Subepithelial deposits “humps”
Classic Presentation of Post Streptococcal Glomerulonephritis
Hematuria Pyuria Red blood cell casts Edema Hypertension Oliguric renal failure
Most common clinical sign of renal disease in Lupus Nephritis
Proteinuria
Class I Lupus Nephritis
Normal Glomerular Histology by any technique or normal light microscopy with minimal mesangial deposits on electron microscope
Class II Lupus Nephritis
Mesangial Immune complexes with mesangial PROLIFERATION
Class III lupus Nephritis
Focal Nephritis
Focal endocapillary with extracapillary proliferation with focal subendothelial immune deposits and mesangial expansions
Class IV Nephritis
Diffuse nephritis
Diffuse endocapillary with =/w/o extracapillary proliferation with diffuse subendothelial immune deposits and mesangial alterations
Class V
Membranous nephritis
Thickened basement membrane with diffuse subepithelial immune deposits
Class VI
Sclerotic nephritis
Global sclerosis of nearly all glomerular capillaries
Pulmonary renal syndrome presents as lung hemorrhage and glomerulonephritis involving collagen IV (alpha 3NC1 domain)
Goodpasture syndrome
HSP is different from IgA nephropathy in that
there is prominent systemic symptoms, younger age (<20 years old), preceding infection and abdominal complaints
2 most common presentation of IgA nephropathy
- Recurrent episodes of Macroscopic hematuria during or immediately following an upper respiratory infection often accompanied by proteinuria
- Persistent asymptomatic microscopic hematuria