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THEME 2.3 ANA PATH > GLOMERULAR DISEASE > Flashcards

GLOMERULAR DISEASE Flashcards

1
Q

PATHOLOGIC RESPONSE OF GLOMERULUS TO INJURY

A

HYPERCELLULARITY-DUE TO PROLIFERATION OF MESENGIAL CELLS OR ENDOTHELIAL CELLS
INFILTRATION OF LEUKOCYTES
FORMATION ON CRESCENTS

BASEMENT MEMBRANE THICKENING–DUE TO DEPOSITION OF ARMPHOUS NMATERIAL(IMMUNE COMPLEXES,FIBRIN,AMYLOID)
INCREEASED SYNTHESIS OF PROTEIN COMPONENTS
FORMATION OF ADDITIONAL LAYERS

HYALINOSIS–ACCUMULATION OF HOMOGENOUS, EOSINOPHILIC MATERIAL
DENOTES ENDOTHELIAL INJURY

SCLEROSIS-DEPOSITION OF COLLAGEN

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2
Q

TWO FORMS OF ANTIBODY-MEDIATED INJURY

A

INJURY BY LOCAL OR IMPLANTED ANTIGENS(MEMBRANOUS NEPHROPATHY)
INJURY BY CIRCULATING ANTIGEN - ANTIBODY COMPLEXES

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3
Q

ENDOGENMOUS AND EXOGENOUS ANTIGENS

A

ENDOGENOUS: SLE, IgA NEPHROPATHY
EXOGENOUS: POST STREPTOCOCCAL HEPATITIS B

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4
Q

ELECTRON DENSE DEPOSIT MAY BE

A

MESENGIAL
SUBEPITHILIAL
SUBENDOTHELIAL

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5
Q

CLINICAL FEATURES

A 
FLUID&ELECTROLYTE:
HYPOKALAEMIA
OEDEMA
DEHYDRATION
METABOLIC ACIDOSIS
CALCIUM PHOSPHATE& BONE
HYPERPHOSPHATEMIA
HYPOCALCAEMIA
SECONDARY HYPERPARATHYROIDISM
RENAL OSTEODYSTROPHY
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6
Q

CLINICAL FEATURES(2)

A

HEMATOLOGIC
ANAEMIA
BLEEDING DIATHESIS

CARDIOPULMONARY
HYPERTENSION
CHF
CARDIOMYOPATHY
PULMONARY OEDEMA
URAEMIC PERICARDITIS
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7
Q

CLINICAL FEATURES(3)

A

GI
NAUSEA AND VOMITTING
BLEEDING
OESOPHEGITIS,GASTRITIS,COLITIS

NEUROMASCULAR
MYOPATHY
PERIPHERAL NEUROPATHY
ENCELO’PATHY

DERMATOLOGIC
SALLOW COLUR
DERMATITID
PRURITIS

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8
Q

PRIMARY GLUMEROPATHIES

A 
ACUTE PROLIFERATIVE GLUMERONEPHRITIS
RAPIDLY PROGRESSIVE GLUMERONEPHRITIS
MEMBRANOPROLIFERATIVE GLUMERONEPHRITIS
FSGC
DENSE DEPOSIT DISEASE
MEMBRANOUS NEPHROPATHY
IgA NEPROPATHY
MINIMAL CHANGE DISEASE
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9
Q

SYSTEMIC DISEASES WITH GLOMERULAR INVOLVEMENT

A 
SLE
AMYLODOSIS
GOOD PASTURE SYNDROME
MICROSCOPIC POLYANGITIS
WEGNER GRANULOMA
HENOCH SCHONLEIN PURPURA
BACTERIAL ENDOCARDITIS
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10
Q

HEREDITARY DISORDERS

A

FABRY DISEASE
ALPOR SYNDROME
THIN MEMBRANE

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11
Q

GLOMERULAR

A 
NEPHROTIC SYNDROME
NEPHRITIC SYNDROME
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS
CHRONIC RENAL FAILURE
ISOLATED URINARY ABNORMALITIES
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12
Q

NEPHROTIC SYNDROME

A 
CAUSED BY DREANGEMENT IN GLOMERULAR CAPILLARY WALL,INCR PERMEABILITY OF PLASMA PROTEIN
MANIFESTATIONS INCLUDE : 
HYPOALBUMINAEMIA
GENERALIZED OEDEMA
HYPERLIPIDAEMIA AND LIIDURIA
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13
Q

CAUSES OF NEPHROTIC(PRIMARY)

A

MEMBRANOUS NEPHROPATHY
MINIMAL CHANGE
FSGS
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AND DENSE DEPOSIT DISEASE

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14
Q

CAUSES OF NEPHROTIC(SYSTEMIC)

A 
DM
AMYLOIDOSIS 
SLE
DRUGS (NSAID PENICILLAMINE,HERION)
INFECTIONS(HIV HEPATITIS B/C SYPHILIS MALARIA
MALIGNANCIES LYMPHOMA CARCINOMA
MISCELLANOUS
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15
Q

NEPHRITIC SYNDROME & MANIFESTATIONS

A

INFLAMMATION ON THE GLUMERULI

HAEMATURIA
RED CELLS CAST IN URINE
AZOTEMIA
OLIGURIAHYPERTENSION

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16
Q

CAUSES OF NEPHRITIC

A

POST INFECTIOUS (POST STREPTOCOCCAL)
CRESENTIC GLUMERONEPHRITIC
SLE

17
Q

CHRONIC GLUMERONEPHRITIS & CAUSES

A

END STAGE,WITH OR WITHOUT ACUTE

CRESCENTIC
MEMBRANOUS NEPHROPATHY
MEMBRANOPROLIFERATIVE GLUMERONEPHRITIS
IgA NEPHROPATHY
FSGC
18
Q

ISOLATED GLOMERUAR ABNORMALITIES

A

IgA

HEREDITARY:ALPORT SYNDROME BENIGN FAMILIAL HEMATURIA

19
Q

MINIMAL CHANGE DISEASE

A

NORMAL HISTOLOGY
DIFFUSED FOOT PROCESSES OF VISCERAL EP CELLS

CAUSES: IMMUNE MEDIATED
ADULTS: NSAID THERAPY HODGKIN LYMPHMA
TUBULAR DROPLETS
DRAMATIC RESPONSETO CORTICOSTEROID

20
Q

MEMBRANOUS NEPHROPATHY

A

DIFFUSE THICKENING OF GLOMERULAR BM
IgG SUBEPITHELIAL DEPOSITS

CAUSES: DRUGS NSAID PENICILAMINE
MALIGNANCY
SLE

21
Q

FOCAL SEGMENTAL GLUMERULOSCLEROSIS AND CAUSES

A

MORPHOLOGY:
SCLEROSIS WITH COLLAPSE OF CAPILLARY LOOPS
INCREASED MATRIX
HYALINOSIS
LIPID DROPLETS & FOAM CELLS

EM:FOOT PROCESSES
DETATCHMENT OF EPITHELIAL CELLS
DENUDATION OF GBM

IDIOPATHIC
HIV
DRUG TOXICITY

22
Q

MEMBRANOPOLIFERATIVE GLOMERULONEPHRITIS

A 
TYPE 1 AND 2
CAUSES: CHRONIC IMMUNE COMPLEX DISORDERS
                SLE
                 HEPATITIS B/C
                 HIV
                SCHIOSTOMASIS
           A1 ANTITRYPSIN DEFICIENCYT
MALIGNANT DISEASE
23
Q

HIVAN

A

ACUTE INTERSTITIAL NEPHRITIS
THROMBOLIC MICOANGIOPATHY
POSTINFECTION GLUMERULONEPHRITIS
COLLAPSING FSGS

24
Q

HIVAN MORPHOLOGIC

A

COLLAPSING VARIANTS OF FSGS
FOCAL CYSTIC DILATION
TUBULORECTICULAR INCLUSIONS WITHIN ENDOTHELIAL CELLS

25
Q

DIABETIC

A

3 LESIONS
GLOMERULA
VASCULAR
PYELONEPHRITIS

MOST IMPORTANT GOMERULAR
CAPILLARY BM THICKENING
DIFFUSE MESENGIAL SCLEROSIS
NODULAR GLUMOROSCLEROSIS

THEME 2.3 ANA PATH (2 decks)

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