GLOMERULAR DISEASE Flashcards
PATHOLOGIC RESPONSE OF GLOMERULUS TO INJURY
HYPERCELLULARITY-DUE TO PROLIFERATION OF MESENGIAL CELLS OR ENDOTHELIAL CELLS
INFILTRATION OF LEUKOCYTES
FORMATION ON CRESCENTS
BASEMENT MEMBRANE THICKENING–DUE TO DEPOSITION OF ARMPHOUS NMATERIAL(IMMUNE COMPLEXES,FIBRIN,AMYLOID)
INCREEASED SYNTHESIS OF PROTEIN COMPONENTS
FORMATION OF ADDITIONAL LAYERS
HYALINOSIS–ACCUMULATION OF HOMOGENOUS, EOSINOPHILIC MATERIAL
DENOTES ENDOTHELIAL INJURY
SCLEROSIS-DEPOSITION OF COLLAGEN
TWO FORMS OF ANTIBODY-MEDIATED INJURY
INJURY BY LOCAL OR IMPLANTED ANTIGENS(MEMBRANOUS NEPHROPATHY)
INJURY BY CIRCULATING ANTIGEN - ANTIBODY COMPLEXES
ENDOGENMOUS AND EXOGENOUS ANTIGENS
ENDOGENOUS: SLE, IgA NEPHROPATHY
EXOGENOUS: POST STREPTOCOCCAL HEPATITIS B
ELECTRON DENSE DEPOSIT MAY BE
MESENGIAL
SUBEPITHILIAL
SUBENDOTHELIAL
CLINICAL FEATURES
FLUID&ELECTROLYTE: HYPOKALAEMIA OEDEMA DEHYDRATION METABOLIC ACIDOSIS
CALCIUM PHOSPHATE& BONE HYPERPHOSPHATEMIA HYPOCALCAEMIA SECONDARY HYPERPARATHYROIDISM RENAL OSTEODYSTROPHY
CLINICAL FEATURES(2)
HEMATOLOGIC
ANAEMIA
BLEEDING DIATHESIS
CARDIOPULMONARY HYPERTENSION CHF CARDIOMYOPATHY PULMONARY OEDEMA URAEMIC PERICARDITIS
CLINICAL FEATURES(3)
GI
NAUSEA AND VOMITTING
BLEEDING
OESOPHEGITIS,GASTRITIS,COLITIS
NEUROMASCULAR
MYOPATHY
PERIPHERAL NEUROPATHY
ENCELO’PATHY
DERMATOLOGIC
SALLOW COLUR
DERMATITID
PRURITIS
PRIMARY GLUMEROPATHIES
ACUTE PROLIFERATIVE GLUMERONEPHRITIS RAPIDLY PROGRESSIVE GLUMERONEPHRITIS MEMBRANOPROLIFERATIVE GLUMERONEPHRITIS FSGC DENSE DEPOSIT DISEASE MEMBRANOUS NEPHROPATHY IgA NEPROPATHY MINIMAL CHANGE DISEASE
SYSTEMIC DISEASES WITH GLOMERULAR INVOLVEMENT
SLE AMYLODOSIS GOOD PASTURE SYNDROME MICROSCOPIC POLYANGITIS WEGNER GRANULOMA HENOCH SCHONLEIN PURPURA BACTERIAL ENDOCARDITIS
HEREDITARY DISORDERS
FABRY DISEASE
ALPOR SYNDROME
THIN MEMBRANE
GLOMERULAR
NEPHROTIC SYNDROME NEPHRITIC SYNDROME RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS CHRONIC RENAL FAILURE ISOLATED URINARY ABNORMALITIES
NEPHROTIC SYNDROME
CAUSED BY DREANGEMENT IN GLOMERULAR CAPILLARY WALL,INCR PERMEABILITY OF PLASMA PROTEIN MANIFESTATIONS INCLUDE : HYPOALBUMINAEMIA GENERALIZED OEDEMA HYPERLIPIDAEMIA AND LIIDURIA
CAUSES OF NEPHROTIC(PRIMARY)
MEMBRANOUS NEPHROPATHY
MINIMAL CHANGE
FSGS
MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS AND DENSE DEPOSIT DISEASE
CAUSES OF NEPHROTIC(SYSTEMIC)
DM AMYLOIDOSIS SLE DRUGS (NSAID PENICILLAMINE,HERION) INFECTIONS(HIV HEPATITIS B/C SYPHILIS MALARIA MALIGNANCIES LYMPHOMA CARCINOMA MISCELLANOUS
NEPHRITIC SYNDROME & MANIFESTATIONS
INFLAMMATION ON THE GLUMERULI
HAEMATURIA
RED CELLS CAST IN URINE
AZOTEMIA
OLIGURIAHYPERTENSION
CAUSES OF NEPHRITIC
POST INFECTIOUS (POST STREPTOCOCCAL)
CRESENTIC GLUMERONEPHRITIC
SLE
CHRONIC GLUMERONEPHRITIS & CAUSES
END STAGE,WITH OR WITHOUT ACUTE
CRESCENTIC MEMBRANOUS NEPHROPATHY MEMBRANOPROLIFERATIVE GLUMERONEPHRITIS IgA NEPHROPATHY FSGC
ISOLATED GLOMERUAR ABNORMALITIES
IgA
HEREDITARY:ALPORT SYNDROME BENIGN FAMILIAL HEMATURIA
MINIMAL CHANGE DISEASE
NORMAL HISTOLOGY
DIFFUSED FOOT PROCESSES OF VISCERAL EP CELLS
CAUSES: IMMUNE MEDIATED
ADULTS: NSAID THERAPY HODGKIN LYMPHMA
TUBULAR DROPLETS
DRAMATIC RESPONSETO CORTICOSTEROID
MEMBRANOUS NEPHROPATHY
DIFFUSE THICKENING OF GLOMERULAR BM
IgG SUBEPITHELIAL DEPOSITS
CAUSES: DRUGS NSAID PENICILAMINE
MALIGNANCY
SLE
FOCAL SEGMENTAL GLUMERULOSCLEROSIS AND CAUSES
MORPHOLOGY:
SCLEROSIS WITH COLLAPSE OF CAPILLARY LOOPS
INCREASED MATRIX
HYALINOSIS
LIPID DROPLETS & FOAM CELLS
EM:FOOT PROCESSES
DETATCHMENT OF EPITHELIAL CELLS
DENUDATION OF GBM
IDIOPATHIC
HIV
DRUG TOXICITY
MEMBRANOPOLIFERATIVE GLOMERULONEPHRITIS
TYPE 1 AND 2
CAUSES: CHRONIC IMMUNE COMPLEX DISORDERS
SLE
HEPATITIS B/C
HIV
SCHIOSTOMASIS
A1 ANTITRYPSIN DEFICIENCYT
MALIGNANT DISEASEHIVAN
ACUTE INTERSTITIAL NEPHRITIS
THROMBOLIC MICOANGIOPATHY
POSTINFECTION GLUMERULONEPHRITIS
COLLAPSING FSGS
HIVAN MORPHOLOGIC
COLLAPSING VARIANTS OF FSGS
FOCAL CYSTIC DILATION
TUBULORECTICULAR INCLUSIONS WITHIN ENDOTHELIAL CELLS
DIABETIC
3 LESIONS
GLOMERULA
VASCULAR
PYELONEPHRITIS
MOST IMPORTANT GOMERULAR
CAPILLARY BM THICKENING
DIFFUSE MESENGIAL SCLEROSIS
NODULAR GLUMOROSCLEROSIS
