Global health

Question 1

4 measures of global health

Answer 1

1. Morbidity rate
2. Mortality rate
3. DALY
4. QALY

Question 2

TOP infectious diseases

Answer 2

COVID19
HIV/AIDs
Ebola
SARS
Malaria
Anthrax
Cholera
Bubonic plague
Flu
Typhoid fever
Smallpox

Question 3

Factors contributing to communicable diseases

Answer 3

Economy - poverty
Systematic barriers
Air pollution & climate change
Mental health
Non-communicable diseases
Fragile/vulnerable settings
Maternal/child health
Nutrition
Inuries
Sexual/gender violence
Wars/conflict/natural disaster
Political/gov infrastructure

Question 4

Malaria transmission

Answer 4

Plasmodium parasite

Question 5

Malaria presentation

Answer 5

Flu, fever, chills, sweats, HA, N/V, body ache

Severe: organ failure, hemoglobinuria, ARDS, hyperparasitemia

Question 6

Malaria tx

Answer 6

Early diagnosis, prompt effective Tx
Use combination therapy:
* Artemether + Lumefantrine
* Artesunate + amodiaquine or mefloquine
* Dihydroartemisinin + piperaquine
* Artesunate + SP

Question 7

Malaria Tx duration

Answer 7

3 days treatment
IV if severe (systemic signs)

Question 8

Artemether + lumefantrine

Answer 8

IM or PO
more lipophillic
CYP3A4 substrate

Question 9

Artesunate + Amodiaquine/Mefloquine

Answer 9

IV or PO
ADR: hypersensitivity, mild GI, rare QT, rare hepatotoxicity
CAUTION: renal/hepatic failure

Question 10

Who do we treat for malaria?

Answer 10

Children and adults
EXCEPT: pregnant women in first trimester